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ChemicalBook >> CAS DataBase List >> Erlotinib D6 HCl

Erlotinib D6 HCl

Erlotinib D6 HCl price.
  • $145 - $1871.1
  • Product name: Erlotinib D6 HCl
  • CAS: 1189953-78-3
  • MF: C22H18ClD6N3O4
  • MW: 435.933630668
  • EINECS:
  • MDL Number:MFCD09840535
  • Synonyms:Erlotinib D6;Erlotinib Hydrochloride Impurity G;[2H6]-Erlotinib Hydrochloride;CP-358774 D6 hydrochloride;NSC 718781 D6 hydrochloride;OSI-774 D6 hydrochloride;Erlotiniβ-d6 Hydrochloride
4 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • TRC
Package
  • 1mg
  • 10MG
  • ManufacturerAK Scientific
  • Product number7728DG
  • Product descriptionErlotinibD6Hydrochloride
  • Packaging1mg
  • Price$409
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006809
  • Product descriptionERLOTINIB-D6-HYDROCHLORIDE 95.00%
  • Packaging10MG
  • Price$1871.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22101
  • Product descriptionErlotinib-d6 (hydrochloride) ≥99% deuterated forms (d1-d6)
  • Packaging1mg
  • Price$279
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberE625002
  • Product descriptionErlotinib-d6Hydrochloride
  • Packaging1mg
  • Price$145
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7728DG ErlotinibD6Hydrochloride 1mg $409 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006809 ERLOTINIB-D6-HYDROCHLORIDE 95.00% 10MG $1871.1 2021-12-16 Buy
Cayman Chemical 22101 Erlotinib-d6 (hydrochloride) ≥99% deuterated forms (d1-d6) 1mg $279 2024-03-01 Buy
TRC E625002 Erlotinib-d6Hydrochloride 1mg $145 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMSO: slightly, heated,Methanol: slightly soluble
form :A solid
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Erlotinib-d6 (hydrochloride) contains six deuterium atoms located on the methoxy group. It is intended for use as an internal standard for the quantification of erlotinib by GC- or LC-MS. Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED50 value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib are used to treat certain forms of cancer, including non-small cell lung cancer.