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ChemicalBook >> CAS DataBase List >> Eplerenone

Eplerenone

Eplerenone price.
  • $44 - $1732.5
  • Product name: Eplerenone
  • CAS: 107724-20-9
  • MF: C24H30O6
  • MW: 414.49
  • EINECS:600-850-8
  • MDL Number:MFCD05662207
  • Synonyms:(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate;HSDB 7522;Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-;Eplerenone intermediate Eplerenone;(7α,11α,17α)-9,11-epoxy-17-hydroxy-3-oxo-γ-lactone-pregn-4-ene-7,21-dicarboxylic acid-7-methyl ester;Eplerenone for system suitability;Eplerenone for peak identification;EPLERENONE
46 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 0.1g
  • y0001706
  • 100MG
  • y0001704
  • 50
  • 200mg
  • 10
  • 250mg
  • 5g
  • 25g
  • 10mM(in 1mL DMSO)
  • y0001705
  • 1g
  • ManufacturerAK Scientific
  • Product numberJ11424
  • Product descriptionEplerenone
  • Packaging10mg
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ11424
  • Product descriptionEplerenone
  • Packaging25mg
  • Price$159
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH899
  • Product descriptionEplerenone
  • Packaging5g
  • Price$254
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH899
  • Product descriptionEplerenone
  • Packaging25g
  • Price$1234
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberRDL0006805
  • Product descriptionEPLERENONE-13C-D3 95.00%
  • Packaging5MG
  • Price$496.51
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002570
  • Product descriptionEPLERENONE 95.00%
  • Packaging5MG
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002570
  • Product descriptionEPLERENONE 95.00%
  • Packaging10MG
  • Price$721.88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002570
  • Product descriptionEPLERENONE 95.00%
  • Packaging100MG
  • Price$1732.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8424
  • Product descriptionEplerenone
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8424
  • Product descriptionEplerenone
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8424
  • Product descriptionEplerenone
  • Packaging25mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134319
  • Product descriptionEplerenone >99%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134319
  • Product descriptionEplerenone >99%
  • Packaging250mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb134319
  • Product descriptionEplerenone >99%
  • Packaging1g
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBE164415
  • Product descriptionEplerenone
  • Packaging10mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBE164415
  • Product descriptionEplerenone
  • Packaging50mg
  • Price$212
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J11424 Eplerenone 10mg $74 2021-12-16 Buy
AK Scientific J11424 Eplerenone 25mg $159 2021-12-16 Buy
AK Scientific H899 Eplerenone 5g $254 2021-12-16 Buy
AK Scientific H899 Eplerenone 25g $1234 2021-12-16 Buy
American Custom Chemicals Corporation RDL0006805 EPLERENONE-13C-D3 95.00% 5MG $496.51 2021-12-16 Buy
American Custom Chemicals Corporation API0002570 EPLERENONE 95.00% 5MG $550 2021-12-16 Buy
American Custom Chemicals Corporation API0002570 EPLERENONE 95.00% 10MG $721.88 2021-12-16 Buy
American Custom Chemicals Corporation API0002570 EPLERENONE 95.00% 100MG $1732.5 2021-12-16 Buy
ApexBio Technology A8424 Eplerenone 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A8424 Eplerenone 10mg $70 2021-12-16 Buy
ApexBio Technology A8424 Eplerenone 25mg $119 2021-12-16 Buy
Biorbyt Ltd orb134319 Eplerenone >99% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb134319 Eplerenone >99% 250mg $765 2021-12-16 Buy
Biorbyt Ltd orb134319 Eplerenone >99% 1g $1504.5 2021-12-16 Buy
Biosynth Carbosynth BE164415 Eplerenone 10mg $72 2021-12-16 Buy
Biosynth Carbosynth BE164415 Eplerenone 50mg $212 2021-12-16 Buy

Properties

Melting point :241-243°C
alpha :D +5° (c = 0.437 in chloroform)
Boiling point :597.9±50.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :DMSO: soluble2mg/mL, clear (warmed)
form :powder
color :white to beige
λmax :240nm(lit.)
Merck :14,3625
InChIKey :UZZAHAKTLYRDOK-MGIDJNSKSA-N
SMILES :[C@@]123[C@@]4(C)CCC(=O)C=C4C[C@@H](C(OC)=O)[C@@]1([H])[C@]1([H])CC[C@]4(CCC(=O)O4)[C@]1(C[C@@]2([H])O3)C |&1:0,1,10,15,17,21,27,29,r|

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Eplerenone is a potassium-sparing diuretic that selectively blocks aldosterone activation of the mineralcorticoid receptor (IC50 = 122 nM), demonstrating little activity towards other steroid receptors (IC50 > 9 μM for glucocorticoid, androgen, progesterone, and estrogen receptors). Aldosterone antagonists such as this compound have been indicated for the treatment of hypertension and heart failure.

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