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ChemicalBook >> CAS DataBase List >> Candesartan cilexetil

Candesartan cilexetil

Candesartan cilexetil price.
  • $6 - $1420
  • Product name: Candesartan cilexetil
  • CAS: 145040-37-5
  • MF: C33H34N6O6
  • MW: 610.66
  • EINECS:627-030-2
  • MDL Number:MFCD00871371
  • Synonyms:1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;Candesantan Cilexetil;1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate;1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2;1-(Cyclohexyloxycarbonyloxy)ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-1H-b;1-(((cyclohexyloxy)carbonyl)oxy)ethylester,(+-)-henyl)-4-yl)methyl) ;1h-benzimidazole-7-carboxylicacid,2-ethoxy-1-((2’-(1h-tetrazol-5-yl)(1,1’-bip ;tcv116
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Brand
  • AHH
  • AK Scientific
  • Ambeed
  • Arctom
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
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  • Tocris
  • TRC
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Package
  • y0001389
  • 5mg
  • 200mg
  • y0001388
  • 250mg
  • 500mg
  • y0001387
  • 10mg
  • 50
  • 50mg
  • 100mg
  • 0.1g
  • 1g
  • 10
  • 2g
  • 5g
  • 10g
  • 25g
  • 100g
  • ManufacturerAHH
  • Product numberAPI-1551
  • Product descriptionCandesartan cilexetil 98%
  • Packaging0.1g
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10436
  • Product descriptionCandesartan cilexetil
  • Packaging100mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ10436
  • Product descriptionCandesartan cilexetil
  • Packaging1g
  • Price$251
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA259269
  • Product description1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+%
  • Packaging10mg
  • Price$6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA259269
  • Product description1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+%
  • Packaging50mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA259269
  • Product description1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+%
  • Packaging1g
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA259269
  • Product description1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+%
  • Packaging5g
  • Price$32
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA259269
  • Product description1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+%
  • Packaging10g
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA259269
  • Product description1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+%
  • Packaging25g
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA259269
  • Product description1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+%
  • Packaging100g
  • Price$477
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS496974
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging10mg
  • Price$6
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS496974
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging50mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS496974
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging1g
  • Price$31
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS496974
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging5g
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS496974
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging10g
  • Price$128
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS496974
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging25g
  • Price$234
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH API-1551 Candesartan cilexetil 98% 0.1g $720 2021-12-16 Buy
AK Scientific J10436 Candesartan cilexetil 100mg $95 2021-12-16 Buy
AK Scientific J10436 Candesartan cilexetil 1g $251 2021-12-16 Buy
Ambeed A259269 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+% 10mg $6 2021-12-16 Buy
Ambeed A259269 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+% 50mg $8 2021-12-16 Buy
Ambeed A259269 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+% 1g $11 2021-12-16 Buy
Ambeed A259269 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+% 5g $32 2021-12-16 Buy
Ambeed A259269 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+% 10g $60 2021-12-16 Buy
Ambeed A259269 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+% 25g $130 2021-12-16 Buy
Ambeed A259269 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 98+% 100g $477 2021-12-16 Buy
Arctom AS496974 Candesartan cilexetil ≥98% 10mg $6 2021-12-16 Buy
Arctom AS496974 Candesartan cilexetil ≥98% 50mg $10 2021-12-16 Buy
Arctom AS496974 Candesartan cilexetil ≥98% 1g $31 2021-12-16 Buy
Arctom AS496974 Candesartan cilexetil ≥98% 5g $65 2021-12-16 Buy
Arctom AS496974 Candesartan cilexetil ≥98% 10g $128 2021-12-16 Buy
Arctom AS496974 Candesartan cilexetil ≥98% 25g $234 2021-12-16 Buy

Properties

Melting point :168-170?C
Boiling point :843.3±75.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥15mg/mL
pka :pKa 3.55 (H2O t=25.0 I=0.025) (Uncertain);5.91(H2O t=25.0 I=0.025) (Uncertain)
form :powder
color :white to beige
λmax :304nm(EtOH)(lit.)
Merck :14,1739
BCS Class :2
InChIKey :GHOSNRCGJFBJIB-UHFFFAOYSA-N
SMILES :C1(OCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C2=C(C(OC(OC(OC3CCCCC3)=O)C)=O)C=CC=C2N=1
CAS DataBase Reference :145040-37-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Candesartan cilexetil is a kind of prodrug being hydrolyzed to candesartan during absorption from the gastrointestinal tract. It appears as a white or off-white powder with a molecular weight of 610.67. It is soluble in methanol but insoluble in water. It is a kind of selective AT1 subtype angiotensin II receptor antagonist, mainly used for the treatment of hypertension and heart failure. Candesartan cilexetil takes effects through selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland, further blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II. Therefore, its mode of action is not through interfering with the pathways for angiotensin II synthesis. Candesartan cilexetil may lead to various kinds of adverse reactions including headache, back pain, dizziness, upper respiratory tract infection, pharyngitis, rhinitis, bronchitis, coughing, sinusitis, nausea, abdominal pain, diarrhea, vomiting, arthralgia and albuminuria. It should be warned that candesartan cilexetil might have remarkable fetal toxicity. Therefore, upon pregnancy, candesartan cilexetil should be discontinued. It could also cause hypotension for heart-failure patients.

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