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ChemicalBook >> CAS DataBase List >> CYLINDROSPERMOPSIN

CYLINDROSPERMOPSIN

CYLINDROSPERMOPSIN price.
  • $154 - $24750
  • Product name: CYLINDROSPERMOPSIN
  • CAS: 143545-90-8
  • MF: C15H21N5O7S
  • MW: 415.42
  • EINECS:
  • MDL Number:MFCD01939922
  • Synonyms:6-[(R)-Hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione;2,4(1h,3h)-pyrimidinedione,6-(hydroxy(2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-( ;5a-alpha,7-beta(r*))-(-)-h ;cylindrospermopsin ;sulfooxy)-1h-1,8,8b-triazaacenaphthylen-7-yl)methyl)-,(2a-alpha,3-alpha,4-alp ;PubChem ID: 42628600;2,4(1H,3H)-Pyrimidinedione, 6-[(R)-hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-
5 prices
Selected condition：
Brand
  • Cayman Chemical
  • TRC
Package
  • 25μg
  • 50μg
  • 100μg
  • 500μg
  • 5mg
  • ManufacturerCayman Chemical
  • Product number10007867
  • Product descriptionCylindrospermopsin ≥95%
  • Packaging500μg
  • Price$1937
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10007867
  • Product descriptionCylindrospermopsin ≥95%
  • Packaging100μg
  • Price$405
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10007867
  • Product descriptionCylindrospermopsin ≥95%
  • Packaging50μg
  • Price$289
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10007867
  • Product descriptionCylindrospermopsin ≥95%
  • Packaging25μg
  • Price$154
  • Updated2023-06-20
  • Buy
  • ManufacturerTRC
  • Product numberC991455
  • Product descriptionCylindrospermopsin
  • Packaging5mg
  • Price$24750
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 10007867 Cylindrospermopsin ≥95% 500μg $1937 2021-12-16 Buy
Cayman Chemical 10007867 Cylindrospermopsin ≥95% 100μg $405 2024-03-01 Buy
Cayman Chemical 10007867 Cylindrospermopsin ≥95% 50μg $289 2024-03-01 Buy
Cayman Chemical 10007867 Cylindrospermopsin ≥95% 25μg $154 2023-06-20 Buy
TRC C991455 Cylindrospermopsin 5mg $24750 2021-12-16 Buy

Properties

Density :1.3937 (rough estimate)
refractive index :1.6460 (estimate)
storage temp. :−20°C
solubility :DMSO: soluble
form :white powder
pka :-3.78±0.18(Predicted)
EPA Substance Registry System :Cylindrospermopsin (143545-90-8)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Cylindrospermopsin is a cyanotoxin alkaloid natural product isolated from Cylindrospermopsis raciborskii blooms. Cylindrospermopsin is an inhibitor of protein synthesis, shown to block the in vitro activity of uridine monophosphate synthase complex. The acute toxicity of Cylindrospermopsin is described to be mediated by CYP (cytochrome p450)-generated metabolites, as inhibitors of CYP (cytochrome p450) completely blocked Cylindrospermopsin toxicity. Decreased activity in reduced glutathione (GSH) synthesis correlated with Cylindrospermopsin exposure may further support the damage caused by metabolites through diminished cellular scavenging of reactive oxygen species. Blockade of CYP (cytochrome p450) by inhibitors also protected cells from Cylindrospermopsin-mediated decreases in GSH levels, indicating that CYP (cytochrome p450)-generated metabolites may also mediate the reduction of GSH synthesis and fall in cellular levels of GSH.

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