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ChemicalBook >> CAS DataBase List >> CCT 244747

CCT 244747

CCT 244747 price.
  • $70 - $1181
  • Product name: CCT 244747
  • CAS: 1404095-34-6
  • MF: C20H24N8O2
  • MW: 408.46
  • EINECS:
  • MDL Number:MFCD25977017
  • Synonyms:CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile;3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile;CCT244747; CCT-244747; CCT 244747;CS-1625;CCT-244747; CCT 244747;2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
22 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1216-M005
  • Product descriptionCCT244747 ≥95%
  • Packaging5mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2857DM
  • Product descriptionCID54758482
  • Packaging5mg
  • Price$326
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging2mg
  • Price$142
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging5mg
  • Price$236
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging10mg
  • Price$394
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging25mg
  • Price$709
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging50mg
  • Price$1181
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging25mg
  • Price$1125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging10mg
  • Price$620
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging5mg
  • Price$390
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging2mg
  • Price$214
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging1mg
  • Price$134
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25666
  • Product descriptionCCT244747 ≥98%
  • Packaging1mg
  • Price$70
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25666
  • Product descriptionCCT244747 ≥98%
  • Packaging5mg
  • Price$207
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25666
  • Product descriptionCCT244747 ≥98%
  • Packaging10mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5919
  • Product descriptionCCT244747 >99.0%
  • Packaging2mg
  • Price$108
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1216-M005 CCT244747 ≥95% 5mg $205 2021-12-16 Buy
AK Scientific 2857DM CID54758482 5mg $326 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 2mg $142 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 5mg $236 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 10mg $394 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 25mg $709 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 50mg $1181 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 25mg $1125 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 10mg $620 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 5mg $390 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 2mg $214 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 1mg $134 2021-12-16 Buy
Cayman Chemical 25666 CCT244747 ≥98% 1mg $70 2024-03-01 Buy
Cayman Chemical 25666 CCT244747 ≥98% 5mg $207 2024-03-01 Buy
Cayman Chemical 25666 CCT244747 ≥98% 10mg $341 2024-03-01 Buy
ChemScene CS-5919 CCT244747 >99.0% 2mg $108 2021-12-16 Buy

Properties

Boiling point :562.6±50.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A solid
pka :8.15±0.28(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G2/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G2 checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.