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ChemicalBook >> CAS DataBase List >> ANSAMITOCIN P-3

ANSAMITOCIN P-3

ANSAMITOCIN P-3 price.
  • $50 - $1200
  • Product name: ANSAMITOCIN P-3
  • CAS: 66547-09-9
  • MF: C32H43ClN2O9
  • MW: 635.14
  • EINECS:
  • MDL Number:MFCD01939731
  • Synonyms:3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-maytansinbutyrate(ester ;Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester);Maytansine, o(sup 3)-de(2-(acetylmethylamino)-1-oxopropyl)-o(sup 3)-(1-oxobutyl)- (9ci);Ansamitocin P-3, >=70%;Maytansinoid AP-3;ANSAMITOCIN P-N;Aansamitocin P3;3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansinebutyrate(ester)
26 prices
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Brand
  • ApexBio Technology
  • BroadPharm
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 250mg
  • 1g
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • ManufacturerApexBio Technology
  • Product numberA3183
  • Product descriptionAnsamitocinP-3
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3183
  • Product descriptionAnsamitocinP-3
  • Packaging10mM(in 1mL DMSO)
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3183
  • Product descriptionAnsamitocinP-3
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3183
  • Product descriptionAnsamitocinP-3
  • Packaging25mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3183
  • Product descriptionAnsamitocinP-3
  • Packaging50mg
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23646
  • Product descriptionMaytansinoidAP-3 95%
  • Packaging25mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23646
  • Product descriptionMaytansinoidAP-3 95%
  • Packaging50mg
  • Price$290
  • Updated2021-12-16
  • Buy
  • ManufacturerBroadPharm
  • Product numberBP-23646
  • Product descriptionMaytansinoidAP-3 95%
  • Packaging100mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20538
  • Product descriptionAnsamitocin P-3 ≥85%
  • Packaging1mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20538
  • Product descriptionAnsamitocin P-3 ≥85%
  • Packaging5mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20538
  • Product descriptionAnsamitocin P-3 ≥85%
  • Packaging10mg
  • Price$302
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20538
  • Product descriptionAnsamitocin P-3 ≥85%
  • Packaging25mg
  • Price$669
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5466
  • Product descriptionAnsamitocinP3'
  • Packaging2mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5466
  • Product descriptionAnsamitocinP3'
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5466
  • Product descriptionAnsamitocinP3'
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5466
  • Product descriptionAnsamitocinP3'
  • Packaging25mg
  • Price$300
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology A3183 AnsamitocinP-3 5mg $90 2021-12-16 Buy
ApexBio Technology A3183 AnsamitocinP-3 10mM(in 1mL DMSO) $120 2021-12-16 Buy
ApexBio Technology A3183 AnsamitocinP-3 10mg $150 2021-12-16 Buy
ApexBio Technology A3183 AnsamitocinP-3 25mg $300 2021-12-16 Buy
ApexBio Technology A3183 AnsamitocinP-3 50mg $490 2021-12-16 Buy
BroadPharm BP-23646 MaytansinoidAP-3 95% 25mg $180 2021-12-16 Buy
BroadPharm BP-23646 MaytansinoidAP-3 95% 50mg $290 2021-12-16 Buy
BroadPharm BP-23646 MaytansinoidAP-3 95% 100mg $420 2021-12-16 Buy
Cayman Chemical 20538 Ansamitocin P-3 ≥85% 1mg $68 2024-03-01 Buy
Cayman Chemical 20538 Ansamitocin P-3 ≥85% 5mg $169 2024-03-01 Buy
Cayman Chemical 20538 Ansamitocin P-3 ≥85% 10mg $302 2024-03-01 Buy
Cayman Chemical 20538 Ansamitocin P-3 ≥85% 25mg $669 2024-03-01 Buy
ChemScene CS-5466 AnsamitocinP3' 2mg $50 2021-12-16 Buy
ChemScene CS-5466 AnsamitocinP3' 5mg $90 2021-12-16 Buy
ChemScene CS-5466 AnsamitocinP3' 10mg $150 2021-12-16 Buy
ChemScene CS-5466 AnsamitocinP3' 25mg $300 2021-12-16 Buy

Properties

Melting point :182-185℃
Boiling point :837.6±65.0 °C(Predicted)
Density :1.30±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
pka :9.83±0.70(Predicted)
form :White to off-white crystalline solid.
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P501 Dispose of contents/container to..…

Description

Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. It binds tubulin (Kd = 1.3 μM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation. Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis. It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.

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