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ChemicalBook >> CAS DataBase List >> 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

$70 - $1871.1
Product name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
CAS: 958852-01-2
MF: C18H11N3O2S
MW: 333.36
EINECS:
MDL Number:MFCD18074517
Synonyms:5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione;GSK 1059615;(5Z)-5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione;GSK 1059615 SodiuM Salt Hydrate;SK1059615;(5Z)-5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione sodium salt hydrate;GSK-615;GSK1059615;GSK 1059615; GSK-1059615

Price27 Properties Safety Information Description

27 prices

Selected condition：

Brand

American Custom Chemicals Corporation
ApexBio Technology
Arctom
Cayman Chemical
Chemenu
ChemScene
Crysdot
Sigma-Aldrich
Tocris
TRC
Usbiological

Package

5mg
50
10MG
10
25mg
50mg
100MG

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0000877
Product descriptionGSK-1059615 95.00%
Packaging10MG
Price$739.2
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberKIN0000877
Product descriptionGSK-1059615 95.00%
Packaging100MG
Price$1871.1
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB2176
Product descriptionGSK1059615
Packaging5mg
Price$80
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB2176
Product descriptionGSK1059615
Packaging10mg
Price$115
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB2176
Product descriptionGSK1059615
Packaging25mg
Price$270
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB2176
Product descriptionGSK1059615
Packaging50mg
Price$495
Updated2021-12-16
Buy

ManufacturerArctom
Product numberCFN60454
Product descriptionGSK1059615
Packaging10mg
Price$288
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number11569
Product descriptionGSK1059615 ≥98%
Packaging5mg
Price$93
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number11569
Product descriptionGSK1059615 ≥98%
Packaging10mg
Price$111
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number11569
Product descriptionGSK1059615 ≥98%
Packaging25mg
Price$252
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number11569
Product descriptionGSK1059615 ≥98%
Packaging50mg
Price$456
Updated2024-03-01
Buy

ManufacturerChemenu
Product numberCM144666
Product description(Z)-5-((4-(Pyridin-4-yl)quinolin-6-yl)methylene)thiazolidine-2,4-dione 98%
Packaging100mg
Price$640
Updated2021-12-16
Buy

ManufacturerChemScene
Product numberCS-0187
Product descriptionGSK1059615 ≥99.0%
Packaging5mg
Price$70
Updated2021-12-16
Buy

ManufacturerChemScene
Product numberCS-0187
Product descriptionGSK1059615 ≥99.0%
Packaging10mg
Price$115
Updated2021-12-16
Buy

ManufacturerChemScene
Product numberCS-0187
Product descriptionGSK1059615 ≥99.0%
Packaging50mg
Price$450
Updated2021-12-16
Buy

ManufacturerChemScene
Product numberCS-0187
Product descriptionGSK1059615 ≥99.0%
Packaging100mg
Price$650
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	KIN0000877	GSK-1059615 95.00%	10MG	$739.2	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000877	GSK-1059615 95.00%	100MG	$1871.1	2021-12-16	Buy
ApexBio Technology	B2176	GSK1059615	5mg	$80	2021-12-16	Buy
ApexBio Technology	B2176	GSK1059615	10mg	$115	2021-12-16	Buy
ApexBio Technology	B2176	GSK1059615	25mg	$270	2021-12-16	Buy
ApexBio Technology	B2176	GSK1059615	50mg	$495	2021-12-16	Buy
Arctom	CFN60454	GSK1059615	10mg	$288	2021-12-16	Buy
Cayman Chemical	11569	GSK1059615 ≥98%	5mg	$93	2024-03-01	Buy
Cayman Chemical	11569	GSK1059615 ≥98%	10mg	$111	2024-03-01	Buy
Cayman Chemical	11569	GSK1059615 ≥98%	25mg	$252	2024-03-01	Buy
Cayman Chemical	11569	GSK1059615 ≥98%	50mg	$456	2024-03-01	Buy
Chemenu	CM144666	(Z)-5-((4-(Pyridin-4-yl)quinolin-6-yl)methylene)thiazolidine-2,4-dione 98%	100mg	$640	2021-12-16	Buy
ChemScene	CS-0187	GSK1059615 ≥99.0%	5mg	$70	2021-12-16	Buy
ChemScene	CS-0187	GSK1059615 ≥99.0%	10mg	$115	2021-12-16	Buy
ChemScene	CS-0187	GSK1059615 ≥99.0%	50mg	$450	2021-12-16	Buy
ChemScene	CS-0187	GSK1059615 ≥99.0%	100mg	$650	2021-12-16	Buy

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Properties

Melting point :>290°C (dec.)
storage temp. :Store at +4°C
solubility :H2O: ≥8mg/mL
form :powder
color :yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PI 3-kinase α (PI3Kα) is a critical regulator of cell growth and transformation. Its signaling pathway is the most commonly mutated pathway in human cancers. GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM) and the common activating mutants of p110α (E542K, E545K, and H1047R) found in cancer. It prevents proliferation in BT474 tumor xenografts and reduces MAPK signaling following twice daily dosing at 25 mg/kg.

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