N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
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- $32 - $2025.29
- Product name: N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
- CAS: 902135-91-5
- MF: C16H18Cl3N5O2
- MW: 418.7
- EINECS:
- MDL Number:MFCD14636428
- Synonyms:N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl;AT 7519;N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride;AT7519 (Hydrochloride);Light yellow solid;4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide Monohydrochloride ;AT 7519 N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride;AT 7519 HCl salt
33 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 5mg
- 10MG
- 1MG
- 10mM(in 1mL DMSO)
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1010-M005
- Product descriptionAT7519hydrochloride ≥95%
- Packaging5mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1010
- Product descriptionAT-7519HCl
- Packaging50mg
- Price$560
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1010
- Product descriptionAT-7519HCl
- Packaging100mg
- Price$890
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002512
- Product description4-(2,6-DICHLOROBENZAMIDO)-N-(PIPERIDIN-4-YL)-1H-PYRAZOLE-3-CARBOXAMIDE HYDROCHLORIDE 95.00%
- Packaging5MG
- Price$497.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005131
- Product descriptionAT-7519 95.00%
- Packaging1MG
- Price$988.4
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005131
- Product descriptionAT-7519 95.00%
- Packaging10MG
- Price$2025.29
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3197
- Product descriptionAT7519Hydrochloride
- Packaging5mg
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3197
- Product descriptionAT7519Hydrochloride
- Packaging10mM(in 1mL DMSO)
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3197
- Product descriptionAT7519Hydrochloride
- Packaging10mg
- Price$117
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3197
- Product descriptionAT7519Hydrochloride
- Packaging50mg
- Price$247
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3197
- Product descriptionAT7519Hydrochloride
- Packaging100mg
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146068
- Product descriptionAT7519 HCL >99%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146068
- Product descriptionAT7519 HCL >99%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146068
- Product descriptionAT7519 HCL >99%
- Packaging1g
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD32785
- Product description4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl
- Packaging25mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD32785
- Product description4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl
- Packaging50mg
- Price$110
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1010-M005 | AT7519hydrochloride ≥95% | 5mg | $108 | 2021-12-16 | Buy |
| AK Scientific | SYN1010 | AT-7519HCl | 50mg | $560 | 2021-12-16 | Buy |
| AK Scientific | SYN1010 | AT-7519HCl | 100mg | $890 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002512 | 4-(2,6-DICHLOROBENZAMIDO)-N-(PIPERIDIN-4-YL)-1H-PYRAZOLE-3-CARBOXAMIDE HYDROCHLORIDE 95.00% | 5MG | $497.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005131 | AT-7519 95.00% | 1MG | $988.4 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005131 | AT-7519 95.00% | 10MG | $2025.29 | 2021-12-16 | Buy |
| ApexBio Technology | A3197 | AT7519Hydrochloride | 5mg | $78 | 2021-12-16 | Buy |
| ApexBio Technology | A3197 | AT7519Hydrochloride | 10mM(in 1mL DMSO) | $86 | 2021-12-16 | Buy |
| ApexBio Technology | A3197 | AT7519Hydrochloride | 10mg | $117 | 2021-12-16 | Buy |
| ApexBio Technology | A3197 | AT7519Hydrochloride | 50mg | $247 | 2021-12-16 | Buy |
| ApexBio Technology | A3197 | AT7519Hydrochloride | 100mg | $325 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146068 | AT7519 HCL >99% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146068 | AT7519 HCL >99% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146068 | AT7519 HCL >99% | 1g | $1802 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD32785 | 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl | 25mg | $70 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD32785 | 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl | 50mg | $110 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :≥29.93 mg/mL in H2O; ≥43.3 mg/mL in DMSO with ultrasonic; ≥8.82 mg/mL in EtOH with ultrasonic
form :crystalline solid
color :White to off-white
solubility :≥29.93 mg/mL in H2O; ≥43.3 mg/mL in DMSO with ultrasonic; ≥8.82 mg/mL in EtOH with ultrasonic
form :crystalline solid
color :White to off-white
Safety Information
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Description
AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.Related product price
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Suppliers and manufacturers
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CONIER CHEM AND PHARMA LIMITED
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
$1.00 /100ASSAYS
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl CAS:902135-91-5
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl CAS:902135-91-5
