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ChemicalBook >> CAS DataBase List >> DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE

DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE

DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE price.
  • $62 - $379
  • Product name: DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
  • CAS: 64005-90-9
  • MF: C22H18N2O8
  • MW: 438.39
  • EINECS:
  • MDL Number:MFCD00333607
  • Synonyms:PIB;DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE;WNKQGFNIIHNGQM-UHFFFAOYSA-N;PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem;Benzo[lmn][3,8]phenanthroline-2,7-diacetic acid, 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-, 2,7-diethyl ester;PiB >=98% (HPLC);PPIase-Parvulin inhibitor,Inhibitor,PPIase Parvulin Inhibitor,PPIaseParvulin Inhibitor,inhibit;diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate
8 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerAK Scientific
  • Product number8702BA
  • Product descriptionPPIase-Parvulin Inhibitor
  • Packaging5mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3022
  • Product descriptionPPIase-Parvulin Inhibitor
  • Packaging5mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3022
  • Product descriptionPPIase-Parvulin Inhibitor
  • Packaging10mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17214
  • Product descriptionPPIase-Parvulin Inhibitor ≥95%
  • Packaging10mg
  • Price$211
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17214
  • Product descriptionPPIase-Parvulin Inhibitor ≥95%
  • Packaging5mg
  • Price$120
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17214
  • Product descriptionPPIase-Parvulin Inhibitor ≥95%
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberB7688
  • Product descriptionPiB ≥98% (HPLC)
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberB7688
  • Product descriptionPiB ≥98% (HPLC)
  • Packaging25mg
  • Price$379
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8702BA PPIase-Parvulin Inhibitor 5mg $185 2021-12-16 Buy
ApexBio Technology C3022 PPIase-Parvulin Inhibitor 5mg $88 2021-12-16 Buy
ApexBio Technology C3022 PPIase-Parvulin Inhibitor 10mg $139 2021-12-16 Buy
Cayman Chemical 17214 PPIase-Parvulin Inhibitor ≥95% 10mg $211 2024-03-01 Buy
Cayman Chemical 17214 PPIase-Parvulin Inhibitor ≥95% 5mg $120 2024-03-01 Buy
Cayman Chemical 17214 PPIase-Parvulin Inhibitor ≥95% 1mg $62 2024-03-01 Buy
Sigma-Aldrich B7688 PiB ≥98% (HPLC) 5mg $118 2024-03-01 Buy
Sigma-Aldrich B7688 PiB ≥98% (HPLC) 25mg $379 2024-03-01 Buy

Properties

storage temp. :2-8°C
solubility :DMSO: soluble1-2mg/mL (warmed)
form :Brownish solid
color :white to light brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Peptidyl-prolyl isomerases (PPIases) assist in the folding of newly-synthesized proteins, regulating the stability, localization, and activity of mature proteins. PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases Pin1 and Pin4 (IC50s = 1.5 and 1.0 μM, respectively), interacting with the PPIase domain. It blocks the proliferation of cancer cells that overexpress Pin1 and Pin4 (IC50 range = 2-5 μM), and similarly inhibits wild type mouse embryonic fibroblasts (MEFs) but not Pin1-/- MEFs. PPIase-Parvulin Inhibitor does not inhibit topoisomerase I or bind DNA. Also referred to as PiB, this compound is commonly used to determine the role of Pin1 in regulating various substrates and cellular functions.