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ChemicalBook >> CAS DataBase List >> Daunorubicin hydrochloride

Daunorubicin hydrochloride

Daunorubicin hydrochloride price.
  • $15 - $1340
  • Product name: Daunorubicin hydrochloride
  • CAS: 23541-50-6
  • MF: C27H29NO10.ClH
  • MW: 563.98
  • EINECS:245-723-4
  • MDL Number:MFCD04974507
  • Synonyms:5,12-Naphthacenedione,8-acetyl-10-[(3-aMino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-Methoxy-,hydrochloride (1:1), (8S,10S)-;daunoblastin ;daunoblastina ;daunomycinchlorohydrate ;ndc0082-4155 ;ondena ;rp13057hydrochloride ;rubidomycinhydrochloride
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  • ManufacturerAK Scientific
  • Product numberQ716
  • Product descriptionDaunorubicinHCl
  • Packaging50mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ60224
  • Product descriptionDaunorubicin hydrochloride
  • Packaging10mg
  • Price$214
  • Updated2024-03-01
  • Buy
  • ManufacturerAmbeed
  • Product numberA148164
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
  • Packaging10mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA148164
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
  • Packaging25mg
  • Price$18
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA148164
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
  • Packaging50mg
  • Price$22
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA148164
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
  • Packaging100mg
  • Price$27
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA148164
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
  • Packaging250mg
  • Price$53
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA148164
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
  • Packaging1g
  • Price$149
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA148164
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+%
  • Packaging5g
  • Price$596
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002223
  • Product descriptionDAUNORUBICIN HYDROCHLORIDE 95.00%
  • Packaging5MG
  • Price$508
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0002223
  • Product descriptionDAUNORUBICIN HYDROCHLORIDE 95.00%
  • Packaging1G
  • Price$675.15
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2285
  • Product descriptionDaunorubicinHCl
  • Packaging10mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS003082
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98%
  • Packaging10mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS003082
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98%
  • Packaging25mg
  • Price$18
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS003082
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98%
  • Packaging50mg
  • Price$22
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS003082
  • Product description(8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98%
  • Packaging100mg
  • Price$27
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Q716 DaunorubicinHCl 50mg $144 2021-12-16 Buy
Alfa Aesar J60224 Daunorubicin hydrochloride 10mg $214 2024-03-01 Buy
Ambeed A148164 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% 10mg $15 2021-12-16 Buy
Ambeed A148164 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% 25mg $18 2021-12-16 Buy
Ambeed A148164 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% 50mg $22 2021-12-16 Buy
Ambeed A148164 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% 100mg $27 2021-12-16 Buy
Ambeed A148164 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% 250mg $53 2021-12-16 Buy
Ambeed A148164 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% 1g $149 2021-12-16 Buy
Ambeed A148164 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride 98+% 5g $596 2021-12-16 Buy
American Custom Chemicals Corporation API0002223 DAUNORUBICIN HYDROCHLORIDE 95.00% 5MG $508 2021-12-16 Buy
American Custom Chemicals Corporation API0002223 DAUNORUBICIN HYDROCHLORIDE 95.00% 1G $675.15 2021-12-16 Buy
ApexBio Technology B2285 DaunorubicinHCl 10mg $50 2021-12-16 Buy
Arctom AS003082 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98% 10mg $15 2021-12-16 Buy
Arctom AS003082 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98% 25mg $18 2021-12-16 Buy
Arctom AS003082 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98% 50mg $22 2021-12-16 Buy
Arctom AS003082 (8S,10S)-8-Acetyl-10-(((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride ≥98% 100mg $27 2021-12-16 Buy

Properties

Melting point :190°C (dec)
alpha :D20 +248 ±5° (c = 0.05-0.1 in methanol)
storage temp. :Inert atmosphere,2-8°C
solubility :Freely soluble in water and in methanol, slightly soluble in alcohol, practically insoluble in acetone.
form :solid
color :red to deep red
Water Solubility :Soluble in water (50 mM)
λmax :477nm(H2O)(lit.)
Sensitive :Hygroscopic
Merck :14,2832
BRN :4229221
Stability :Stability
InChIKey :GUGHGUXZJWAIAS-SMLRDAARNA-N
SMILES :C1=CC2C(=O)C3=C(O)C4C[C@](C(C)=O)(O)C[C@H](O[C@@H]5O[C@@H](C)[C@@H](O)[C@@H](N)C5)C=4C(O)=C3C(=O)C=2C(OC)=C1.Cl |&1:10,16,18,20,22,24,r|
EPA Substance Registry System :Daunorubicin hydrochloride (23541-50-6)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Daunorubicin is an antitumor antibiotic widely used in the treatment of acute myeloid leukemias (AMLs). At 0.2-1μM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 AML cells. However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations. In mature AML cells, daunorubicin has been shown to trigger a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.

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