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ChemicalBook >> CAS DataBase List >> 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol

2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol

2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol price.
  • $37 - $1140
  • Product name: 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol
  • CAS: 1359164-11-6
  • MF: C26H24F7N3O
  • MW: 527.48
  • EINECS:
  • MDL Number:MFCD25563263
  • Synonyms:2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol;SR-2211;2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol (SR 2211);[1,1'-Biphenyl]-4-methanol, 2-fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-;2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol;SR-2211,SR2211;1,1,1,3,3,3-Hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol;SR2211, 10 mM in DMSO
13 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Tocris
  • TRC
Package
  • 5mg
  • 50
  • 1mg
  • 10
  • 10mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product numberSYN5040
  • Product descriptionSR-2211
  • Packaging10mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5040
  • Product descriptionSR-2211
  • Packaging100mg
  • Price$1140
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5743
  • Product descriptionSR2211
  • Packaging10mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5743
  • Product descriptionSR2211
  • Packaging5mg
  • Price$151
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11972
  • Product descriptionSR 2211 ≥98%
  • Packaging10mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11972
  • Product descriptionSR 2211 ≥98%
  • Packaging5mg
  • Price$134
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11972
  • Product descriptionSR 2211 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0013508
  • Product descriptionSR2211 98.59%
  • Packaging10mg
  • Price$230
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0013508
  • Product descriptionSR2211 98.59%
  • Packaging5mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4869
  • Product descriptionSR2211 ≥98%(HPLC)
  • Packaging50
  • Price$926
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4869
  • Product descriptionSR2211 ≥98%(HPLC)
  • Packaging10
  • Price$223
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberF595930
  • Product description2-Fluoro-4''-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1''-biphenyl]-4-methanol
  • Packaging5mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberF595930
  • Product description2-Fluoro-4''-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1''-biphenyl]-4-methanol
  • Packaging50mg
  • Price$1050
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5040 SR-2211 10mg $225 2021-12-16 Buy
AK Scientific SYN5040 SR-2211 100mg $1140 2021-12-16 Buy
ApexBio Technology B5743 SR2211 10mg $182 2021-12-16 Buy
ApexBio Technology B5743 SR2211 5mg $151 2021-12-16 Buy
Cayman Chemical 11972 SR 2211 ≥98% 10mg $161 2024-03-01 Buy
Cayman Chemical 11972 SR 2211 ≥98% 5mg $134 2024-03-01 Buy
Cayman Chemical 11972 SR 2211 ≥98% 1mg $37 2024-03-01 Buy
ChemScene CS-0013508 SR2211 98.59% 10mg $230 2021-12-16 Buy
ChemScene CS-0013508 SR2211 98.59% 5mg $130 2021-12-16 Buy
Tocris 4869 SR2211 ≥98%(HPLC) 50 $926 2021-12-16 Buy
Tocris 4869 SR2211 ≥98%(HPLC) 10 $223 2021-12-16 Buy
TRC F595930 2-Fluoro-4''-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1''-biphenyl]-4-methanol 5mg $130 2021-12-16 Buy
TRC F595930 2-Fluoro-4''-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1''-biphenyl]-4-methanol 50mg $1050 2021-12-16 Buy

Properties

Boiling point :552.4±50.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
form :Powder
pka :8.85±0.19(Predicted)
color :Off-white to light brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 2211 selectively binds RORγ (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORγ activity (IC50 = 320 nM). It has minimal effects on RORα, LXRα, and FXR activities. SR 2211 significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 μM.

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