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ChemicalBook >> CAS DataBase List >> N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1)

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1)

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) price.
  • $79 - $8853.08
  • Product name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1)
  • CAS: 1146618-41-8
  • MF: C19H19ClN6O4S3
  • MW: 527.03996
  • EINECS:
  • MDL Number:MFCD16621142
  • Synonyms:SNS-314 mesylate, >=98%;N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1);SNS-314 Mesylate;M1-(3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea Mesylate;N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) SNS-314 Mesylate;1-(3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea methanesulfonate;N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate;SNS-314 MESYLATE; SNS314; SNS 314
34 prices
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  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
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  • 50mg
  • 100mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberX7391
  • Product descriptionSNS-314 mesylate
  • Packaging10mg
  • Price$232
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA405855
  • Product descriptionSNS-314 mesylate 98+%
  • Packaging100mg
  • Price$951
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000887
  • Product descriptionSNS-314 MESYLATE 95.00%
  • Packaging10MG
  • Price$970.2
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000887
  • Product descriptionSNS-314 MESYLATE 95.00%
  • Packaging100MG
  • Price$2243.59
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000887
  • Product descriptionSNS-314 MESYLATE 95.00%
  • Packaging1G
  • Price$8853.08
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4121
  • Product descriptionSNS-314 mesylate
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4121
  • Product descriptionSNS-314 mesylate
  • Packaging10mM(in 1mL DMSO)
  • Price$128
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4121
  • Product descriptionSNS-314 mesylate
  • Packaging10mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4121
  • Product descriptionSNS-314 mesylate
  • Packaging50mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA4121
  • Product descriptionSNS-314 mesylate
  • Packaging200mg
  • Price$1180
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2906
  • Product descriptionSNS-314 mesylate 99%
  • Packaging5mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2906
  • Product descriptionSNS-314 mesylate 99%
  • Packaging25mg
  • Price$297
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181027
  • Product descriptionSNS-314 Mesylate >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS43317
  • Product descriptionSNS 314 Mesylate
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFS43317
  • Product descriptionSNS 314 Mesylate
  • Packaging50mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14974
  • Product descriptionSNS-314 (mesylate) ≥98%
  • Packaging1mg
  • Price$81
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7391 SNS-314 mesylate 10mg $232 2021-12-16 Buy
Ambeed A405855 SNS-314 mesylate 98+% 100mg $951 2021-12-16 Buy
American Custom Chemicals Corporation INB0000887 SNS-314 MESYLATE 95.00% 10MG $970.2 2021-12-16 Buy
American Custom Chemicals Corporation INB0000887 SNS-314 MESYLATE 95.00% 100MG $2243.59 2021-12-16 Buy
American Custom Chemicals Corporation INB0000887 SNS-314 MESYLATE 95.00% 1G $8853.08 2021-12-16 Buy
ApexBio Technology A4121 SNS-314 mesylate 5mg $85 2021-12-16 Buy
ApexBio Technology A4121 SNS-314 mesylate 10mM(in 1mL DMSO) $128 2021-12-16 Buy
ApexBio Technology A4121 SNS-314 mesylate 10mg $145 2021-12-16 Buy
ApexBio Technology A4121 SNS-314 mesylate 50mg $470 2021-12-16 Buy
ApexBio Technology A4121 SNS-314 mesylate 200mg $1180 2021-12-16 Buy
Axon Medchem Axon2906 SNS-314 mesylate 99% 5mg $99 2021-12-16 Buy
Axon Medchem Axon2906 SNS-314 mesylate 99% 25mg $297 2021-12-16 Buy
Biorbyt Ltd orb181027 SNS-314 Mesylate >98% 100mg $615.4 2021-12-16 Buy
Biosynth Carbosynth FS43317 SNS 314 Mesylate 10mg $135 2021-12-16 Buy
Biosynth Carbosynth FS43317 SNS 314 Mesylate 50mg $350 2021-12-16 Buy
Cayman Chemical 14974 SNS-314 (mesylate) ≥98% 1mg $81 2024-03-01 Buy

Properties

storage temp. :-20°
solubility :Soluble in DMSO (up to at least 25 mg/ml).
form :solid
color :Off-white
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively). In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM). SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg. It also inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models when administered biweekly for six weeks at a dose of 170 mg/kg.

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