Sertraline hydrochloride
Product identifier
- Product name: Sertraline hydrochloride
- CBnumber: CB8157645
- CAS: 79559-97-0
- EINECS Number: 616-702-0
- Synonyms: SERTRALINE HYDROCHLORIDE,Sertaline hydrochloride
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: Sertraline hydrochloride
- Synonyms: SERTRALINE HYDROCHLORIDE,Sertaline hydrochloride
- CAS: 79559-97-0
- EC number: 616-702-0
- MF: C17H18Cl3N
- MW: 342.69
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
No data available
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Information on basic physicochemical properties
- Appearance solid
- OdourNo data available
- Odour ThresholdNo data available
- pHNo data available
- Melting point/freezing pointMelting point/range: 243 - 245 °C
- Initial boiling point and boiling rangeNo data available
- Flash point9℃
- Evaporation rateNo data available
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limitsNo data available
- Vapour pressureNo data available
- Vapour densityNo data available
- Relative densityNo data available
- Water solubilityDMSO: ~26 mg/mL
- Partition coefficient: n-octanol/waterNo data available
- Autoignition temperatureNo data available
- Decomposition temperatureNo data available
- ViscosityNo data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
Other safety information
No data available
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
No data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Other decomposition products - No data available In the event of fire: see section 5
Information on toxicological effects
Acute toxicityRemarks: Behavioral:Convulsions or effect on seizure threshold. Behavioral:Food intake (animal). Gastrointestinal:Changes in structure or function of salivary glands.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Toxicity
EC50 - Daphnia magna (Water flea) - 0,92 mg/l - 48 h
Persistence and degradability
No data available
Bioaccumulative potential
No data available
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
Contaminated packaging
Dispose of as unused product.
UN number
ADR/RID: 3077 IMDG: 3077 IATA: 3077
UN proper shipping name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. () IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ()
IATA: Environmentally hazardous substance, solid, n.o.s. ()
Transport hazard class(es)
ADR/RID: 9 IMDG: 9 IATA: 9
Packaging group
ADR/RID: III IMDG: III IATA: III
Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
Special precautions for user
Further information
EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- CAS: Chemical Abstracts Service
- EC50: Effective Concentration 50%
- IATA: International Air Transportation Association
- IMDG: International Maritime Dangerous Goods
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- STEL: Short term exposure limit
- TWA: Time Weighted Average
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.