Ethyl chloroacetate
Product identifier
- Product name: Ethyl chloroacetate
- CBnumber: CB9852655
- CAS: 105-39-5
- EINECS Number: 203-294-0
- Synonyms: Ethyl chloroacetate,chloroacetic acid ethyl ester
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Acute toxicity - Category 3, Inhalation
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Label elements
Pictogram(s)
- Signal wordDanger
H226 Flammable liquid and vapour
H301 Toxic if swalloed
H310 Fatal in contact with skin
H311 Toxic in contact with skin
H315 Causes skin irritation
H317 May cause an allergic skin reaction
H318 Causes serious eye damage
H331 Toxic if inhaled
H371 May cause damage to organs
H400 Very toxic to aquatic life
H401 Toxic to aquatic life
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: Ethyl chloroacetate
- Synonyms: Ethyl chloroacetate,chloroacetic acid ethyl ester
- CAS: 105-39-5
- EC number: 203-294-0
- MF: C4H7ClO2
- MW: 122.55
Description of first aid measures
If inhaledFresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Give one or two glasses of water to drink. Refer for medical attention .
Most important symptoms and effects, both acute and delayed
Inhalation causes irritation of mucous membrane, headache, and nausea. Contact with liquid causes extreme eye irritation and conjunctivitis; irritates skin if not removed at once. Ingestion causes irritation of mouth and stomach. (USCG, 1999)
Indication of any immediate medical attention and special treatment needed
Absorption, Distribution and ExcretionMay be absorbed percutaneously...
Extinguishing media
To fight fire, use water, foam, carbon dioxide, dry chemical.
Specific Hazards Arising from the Chemical
Special Hazards of Combustion Products: Irritating, toxic hydrogen chloride and phosgene may be generated in fires. (USCG, 1999)
Advice for firefighters
Use water spray, dry powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water.
NFPA 704
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Remove all ignition sources. Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in covered plastic containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Remove all ignition sources. Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in covered plastic containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 53°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Fireproof. Separated from incompatible materials and food and feedstuffs. See Chemical Dangers. Dry.
Control parameters
Occupational Exposure limit values| Component | Ethyl chloroacetate | |||
|---|---|---|---|---|
| CAS No. | 105-39-5 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Austria | 1 | 5 | 1 | 5 |
| Germany (AGS) | 1 | 5 | 1 (1) | 5 (1) |
| Remarks | ||||
| Germany (AGS) | (1) 15 minutes average value | |||
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear face shield or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateLiquid
- ColourClear colorless
- Odour
Fruity pungent odor
- Melting point/freezing point
-21 °C.
- Boiling point or initial boiling point and boiling range
144.3 °C. Atm. press.:101 325 Pa.
- Flammability
Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
- Lower and upper explosion limit/flammability limit2.6%(V)
- Flash point
56 °C. Atm. press.:101.3 kPa.
- Auto-ignition temperature
445 °C. Atm. press.:100.9 kPa.
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
dynamic viscosity (in mPa s) = 1.27. Temperature:20°C.
- Solubility12.3g/l
- Partition coefficient n-octanol/water
log Pow = 0.94.
- Vapour pressure10 mm Hg ( 38 °C)
- Density and/or relative density
1.16 g/cm3.
- Relative vapour density
4.23-4.46
- Particle characteristics
no data available
Reactivity
Decomposes on burning. This produces toxic and corrosive gases including hydrogen chloride and acetic acid fumes. Reacts with water, moist air and acids. This produces hydrogen chloride. Reacts with bases, oxidants and reducing agents.
Chemical stability
no data available
Possibility of hazardous reactions
FLAMMABLE LIQUID; A DANGEROUS FIRE HAZARD WHEN EXPOSED TO HEAT OR FLAME ...The vapour is heavier than air.ETHYL CHLOROACETATE is a chlorinated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Conditions to avoid
no data available
Incompatible materials
Can react vigorously with oxidizing materials. will react with water or steam to produce toxic & corrosive fumes. vigorous reaction with sodium cyanide.
Hazardous decomposition products
When heated to decomp, it emits highly toxic fumes of /hydrogen chloride/.
Acute toxicity
- Oral: LD50 - rat (female) - 180 mg/kg bw.
- Inhalation: LC50 - rat (male/female) - 3.33 mL/m3.
- Dermal: LD50 - rat (female) - 161.2 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is severely irritating to the eyes. The substance is moderately irritating to the skin and respiratory tract.
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
Toxicity
- Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - 1.48 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 1.6 mg/L - 48 h.
- Toxicity to algae: EC50 - 20.8 mg/L - 48 h.
- Toxicity to microorganisms: EC0 - anaerobic bacteria from a domestic water treatment plant - 900 mg/L - 24 h.
Persistence and degradability
no data available
Bioaccumulative potential
An estimated BCF of 3 was calculated for ethyl chloroacetate(SRC), using a log Kow of 0.94(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.
Mobility in soil
The Koc of ethyl chloroacetate is estimated as 12(SRC), using a log Kow of 0.94(1). According to a classification scheme(3), this estimated Koc value suggests that ethyl chloroacetate is expected to have very high mobility in soil.
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN1181 (For reference only, please check.)
IMDG: UN1181 (For reference only, please check.)
IATA: UN1181 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ETHYL CHLOROACETATE (For reference only, please check.)
IMDG: ETHYL CHLOROACETATE (For reference only, please check.)
IATA: ETHYL CHLOROACETATE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: II (For reference only, please check.)
IMDG: II (For reference only, please check.)
IATA: II (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Explosive limits are unknown in literature, although the substance is combustible and has a flash point < 61°C.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.