1,4-Dioxane
Product identifier
- Product name: 1,4-Dioxane
- CBnumber: CB6240532
- CAS: 123-91-1
- EINECS Number: 204-661-8
- Synonyms: 1,4-dioxane,diox
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
Substance
- Product name: 1,4-Dioxane
- Synonyms: 1,4-dioxane,diox
- CAS: 123-91-1
- EC number: 204-661-8
- MF: C4H8O2
- MW: 88.11
Description of first aid measures
General adviceMost important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Extinguishing media
Suitable extinguishing mediaSpecial hazards arising from the substance or mixture
Carbon oxides Combustible.
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
Further information
Use water spray to cool unopened containers.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 3 | Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations (see section 13).
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Advice on safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Advice on protection against fire and explosion
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
control parameter
Hazard composition and occupational exposure limitsExposure controls
Personal protective equipmentFace shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact
Material: butyl-rubber
Minimum layer thickness: 0,3 mm Break through time: 480 min
Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)
Splash contact Material: Chloroprene
Minimum layer thickness: 0,6 mm Break through time: 35 min
Material tested:Camapren? (KCL 722 / Aldrich Z677493, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Information on basic physicochemical properties
- Appearancecolorless liquid
- OdourNo data available
- Odour ThresholdNo data available d) pH 6,0 - 8 at 500 g/l at 20 °C Melting point/freezing point Initial boiling point and boiling range Melting point/range: 10 - 12 °C - lit. 100 - 102 °C - lit. Flash point 11 °C - closed cup Evaporation rate No data available Flammability (solid, gas) Upper/lower flammability or explosive limits No data available Upper explosion limit: 22 %(V) Lower explosion limit: 2 %(V) Vapour pressure 36 hPa at 20 °C 53 hPa at 25,20 °C Vapour density 3,04 - (Air = 1.0) Relative density 1,03 at 20 °C Water solubility 1.000 g/l at 20 °C - completely miscible Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature log Pow: -0,42 - Bioaccumulation is not expected. 190,55 °C No data available Viscosity Viscosity, kinematic: 1,27 mm2/s at 20 °C - OECD Test Guideline 1140,93 mm2/s at 40 °C - OECD Test Guideline 114 Viscosity, dynamic: No data available Explosive properties No data available Oxidizing properties No data available
- Melting point/freezing pointMelting point/range: 10 - 12 °C - lit.
- Initial boiling point and boiling range 100 - 102 °C - lit.
- Flash point11 °C - closed cup
- Evaporation rate54 °F
- Flammability (solid, gas)No data available
- Upper/lower flammability or explosive limits Upper explosion limit: 22 %(V) Lower explosion limit: 2 %(V)
- Vapour pressure 36 hPa at 20 °C 53 hPa at 25,20 °C
- Vapour density 3,04 - (Air = 1.0)
- Relative density1,03 at 20 °C
- Water solubility1.000 g/l at 20 °C - completely miscible
- Partition coefficient: n-octanol/waterlog Pow: -0,42 - Bioaccumulation is not expected.
- Autoignition temperaturelog Pow: -0,42 - Bioaccumulation is not expected.
- Decomposition temperatureNo data available
- ViscosityViscosity, kinematic: 1,27 mm2/s at 20 °C - OECD Test Guideline 1140,93 mm2/s at 40 °C - OECD Test Guideline 114 Viscosity, dynamic: No data available
- Explosive propertiesNo data available
- Oxidizing propertiesNo data available
- Henry's Law Constant4.89(x 10-6 atm?m3/mol) (static headspace-GC, Welke et al., 1998)
- λmaxλ: 220 nm Amax: ≤0.70
λ: 235 nm Amax: ≤0.50
λ: 250 nm Amax: ≤0.20
λ: 270 nm Amax: ≤0.10
λ: 295-400 nm Amax: ≤0.01
Other safety information
Surface tension 36,9 mN/m at 25 °C
Relative vapor density
3,04 - (Air = 1.0)
Reactivity
No data available
Chemical stability
Stable under recommended storage conditions. Stable under recommended storage conditions.
Possibility of hazardous reactions
No data available
Conditions to avoid
Heat, flames and sparks.
Incompatible materials
Oxygen, Oxidizing agents, Halogens, Reducing agents, Perchlorates., Trimethylaluminum
Hazardous decomposition products
In the event of fire: see section 5
Information on toxicological effects
Acute toxicitySymptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract, Lung edema
LD50 Dermal - Rabbit - 7.378 mg/kg Remarks:
(RTECS)
Result: No skin irritation - 20 h Remarks:
(IUCLID)
(OECD Test Guideline 405)
(Regulation (EC) No 1272/2008, Annex VI)
Salmonella typhimurium Result: negative
In vitro mammalian cell gene mutation test
Chinese hamster ovary cells Result: negative
Chromosome aberration test in vitro Chinese hamster ovary cells
Result: negative Remarks:
(ECHA)
Mouse - male Result: negative Remarks:
(ECHA)
IARC: 2B - Group 2B: Possibly carcinogenic to humans (1,4-Dioxane)
Toxicity
semi-static test EC50 - Daphnia magna (Water flea) - > 1.000 mg/l
- 48 h
(OECD Test Guideline 202)
1.000 mg/l - 72 h
(OECD Test Guideline 201)
Persistence and degradability
Biodegradability aerobic - Exposure time 29 d
Result: < 10 % - Not readily biodegradable. (OECD Test Guideline 301F)
Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 10 mg/l(1,4-Dioxane)
Bioconcentration factor (BCF): 0,3 - 0,7 (OECD Test Guideline 305C)
Mobility in soil
No data available
Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Other adverse effects
Forms toxic mixtures in water, dilution measures notwithstanding. Discharge into the environment must be avoided.
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
IncompatibilitiesDioxane can form potentially explosive peroxides upon long exposure to air. Dioxane may react violently with Raney nickel catalyst, nitric and perchloric acids, sulfur trioxide, and strong oxidizing reagents.
Waste DisposalExcess dioxane and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution''s waste disposal guidelines.
Contaminated packaging
Dispose of as unused product.
UN number
UN proper shipping name
Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
No data available
Safety, health and environmental regulations/legislation specific for the substance or mixture
Regulations on the Safety Management of Hazardous ChemicalsAbbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/
【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/
Other Information
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.