Can the use of blood sampling additives cause hemolysis?

 

Hemolysis refers to the phenomenon of red blood cells breaking and hemoglobin escaping from the cells. In general, the quality of blood samples determines the quality of test results. Blood samples that undergo hemolysis have an impact on items such as proteins; Due to the significantly higher levels of intracellular potassium ions compared to extracellular ones, hemolysis can also affect the detection of electrolyte items. Therefore, blood samples with hemolysis cannot undergo subsequent examinations, and a better solution is to collect blood again.

 

Generally, blood samples with hemolysis phenomenon are unqualified samples, as they can affect the accuracy of many test results, so these samples usually need to be rejected. But there are also some situations that need to be handled as appropriate:

 

1. Blood samples from newborns. Some newborns are premature, with low weight, thin blood vessels, and high difficulty in collecting blood. Even if there is hemolysis in the blood sample, it will not be rejected because hemolysis is inevitable to occur again during blood collection.

 

2. Blood samples of patients with intravascular hemolysis who have undergone heart valve and Great vessels surgery. Collecting blood again may cause new harm to the patient, so hemolysis that has little impact on the test items will not be rejected after communicating with the clinical physician.

 

There are many reasons that can cause hemolysis in blood samples. Firstly, the phenomenon of hemolysis is caused by prolonged pressure band ligation during blood collection, excessive suction force, fast blood collection speed, difficulty in blood collection, and air mixing in the blood collection vessels; Secondly, the occurrence of strong vibrations or sudden low-temperature freezing or thawing during transportation and storage of blood samples outside the body can also cause hemolysis; Finally, during testing, excessive centrifugation speed or other factors may cause hemolysis.

 

Based on relevant literature and the above analysis, it has been found that there are many cases of hemolysis in blood samples caused by external factors, and no causal relationship has been found between the use of blood sampling additives and the occurrence of hemolysis in blood samples. However, it cannot be ruled out that low-quality blood sampling additives can cause hemolysis in blood samples. Therefore, when purchasing high-quality blood sampling additives, remember to identify Hubei Xindesheng Material Technology Co., Ltd