Principle of action of heparin lithium anticoagulant

 

In many items of blood testing, heparin sodium is often selected as an anticoagulant, which is particularly suitable for measuring the ion content in the blood because it has the smallest interference impact on other ion measurements. Heparin lithium often appears in clinical and emergency biochemical tests, so what is its anticoagulation mechanism?

 

Lithium heparin is actually a mucopolysaccharide containing sulfate groups extracted from the intestinal mucosa of pigs, cattle, and sheep. It is a biologically active substance with a strong negative charge, and has anticoagulant effects both in vivo and in vitro, affecting all three stages of the coagulation process:

 

1. Inhibit the formation of prothrombin kinase, enhance the activity of antithrombin III, and promote the inactivation of coagulation factors, thereby inhibiting and resisting the formation of prothrombin kinase.

 

2. Interference with the action of thrombin affects the formation of insoluble fibrin by interfering with the activity of thrombin factors, and also inhibits the conversion of fibrinogen to fibrin, thereby preventing the action of thrombin.

 

3. Prevents platelet aggregation, prevents platelet disintegration, and releases platelet factors and serotonin.

 

The anticoagulant effect of heparin lithium is not unique, but rather affects multiple aspects of the coagulation process, working together to achieve good anticoagulant effects. It should be noted that the heparin lithium in the blood collection vessel should be fully mixed with the blood sample during use to avoid partial coagulation; On the other hand, the anticoagulant effect of heparin lithium is not irreversible, so the heparin lithium tube should complete the corresponding test items within six hours after blood collection, otherwise the test results will be affected.

 

Hubei Xindesheng Material Technology Co., Ltd. has specialized in the research and development of heparin lithium for 18 years. Its production technology has been leading many peer manufacturers, and the product quality has also been recognized by the majority of users at home and abroad. It has unique advantages in the market of blood collection additives. Currently, Desheng produces a series of blood collection additives including heparin lithium. If you are a blood collection manufacturer, please choose Desheng Company to meet your one-stop shopping experience