Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 is a powerful silylating agent used for the protection of amides, amines, alcohols, carboxylic acids, enols, and phenols . It can also be used as a Bronsted base precursor in Tsuji–Trost reactions  

What are properties of Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 ?

Molecular weight: 203.43 g/mol

Boiling point: 75-77 ° C (20 mmHg)

Density: 0.82 g/cm ³ (25 ° C)

Refractive index: 1.408 (25 ° C)

Appearance: Colorless transparent liquid

Solubility: soluble in most organic solvents, such as toluene, chloroform, ether, etcinsoluble in water.

What are main application areas of Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 ?

1. Organic synthesis

Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 is mainly used as a trimethylsilylation reagent in organic synthesis, which can protect functional groups such as hydroxyl and amino groups and prevent side reactions during the synthesis process. Due to the excellent stability and easy deprotection of trimethylsilyl groups, BSA has been widely used in organic synthesis.

2. Analytical Chemistry

In analytical chemistry, Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 is used as a derivatization reagent, especially in gas chromatography (GC) and liquid chromatography (LC) analysis, to generate volatile derivatives through reaction with analytes, which is convenient for detection and quantitative analysis. This is of great significance for the separation and analysis of complex mixtures.

3. Biochemistry

In biochemical research, Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 can be used to modify biomolecules, improve their stability and detection sensitivity. For example, in proteomics and metabolomics research, BSA derivatization can improve the detection efficiency and accuracy of proteins and metabolites.

4. Pharmaceutical Chemistry

The application of Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 in pharmaceutical chemistry is becoming increasingly widespread, especially in drug molecule design and synthesis. By introducing trimethylsilyl groups, the physical and chemical properties of drug molecules can be improved, such as solubility, stability, and bioavailability.

What are usage methods of Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 ?

The usage methods of Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 mainly include two methods: direct reaction and solution reaction

Direct reaction:

Directly add BSA to the reaction system and react with the compounds to be protected or derivatized. The reaction conditions are usually mild and can generally be completed at room temperature. The post reaction products are purified through conventional separation and purification methods such as evaporation, recrystallization, or column chromatography.

Solution reaction

Dissolve BSA in appropriate organic solvents (such as toluene, ether, etc.), and then add the solution to the reaction system. This method is suitable for situations that require precise control of reaction conditions or large-scale reactions. After the reaction, the product was also separated and purified using conventional methods.

What is the market prospect of Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 ?

With the continuous development of organic synthesis technology and the emergence of various new materials and drugs, the market demand for Bis(trimethylsilyl)acetamide(BSA) CAS NO.10416-59-8 is also increasing year by year. Especially in analytical techniques such as high-performance liquid chromatography (HPLC) and gas chromatography (GC), as well as in the field of biomedicine, BSA, as an important derivative and protective reagent, has broad application prospects.

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