Dihydroartemisinin

Product Type： Pure Plant Extracts

Usage： Pharmaceutical raw materials

Clicks： 1654

Release Time： 2013-01-21

Introduction

Product name : Dihydroartemisinin

CAS:  81496-82-4 

Molecular formula:C15H24O5                                                                                                                                                                                                                                  Molecular weight: 284.35  

Specification : 98%,99% (HPLC)

Latin Name :Artemisia annua L

Character : Fine white powder

Extraction origin : Dry leaf of Artemisia annua L．

   Dihydroartemisinin chemical designation is (3R,5aS,6R,8aS,9R,12S,12aR)- octahydro-3,6,9-trimethyl-3, 12-epoxy- 12H-pyrano[4.3-j]-1,2-benzodioxepin-10(3H)-one. Malaria is one of leading re-emerging infectious disease due to murative malarial parasite developed resistance to chloroquine. Sulfadoxine pyrimethamine is an 

alternative can be used in the treatment of the disease resistant to chloroquine, but resistance to sulfadoxine-pyrimethamine has been reported also in some areas. Artemisinin is an alternative used in areas where the disease has become highly resistant to sulfadoxine pyrimethamine. Dihydroartemisinin, its methyl ether (artemether), its ehyl ether (its (arteether) and its hemisuccinate ester (artesunate) are known as more effective than

its parent material - artemisinin. Artemisinin is a peroxidebridged sesquiterpene lactone compound which has no N atom, unlike quinine class anti-malarial drugs. The characteristic peroxide lactone structure is indispensable for anti-malarial activity. The term of artemotil refers to the pure beta-epimer of arteether.