Myricetin

Molecular Formula: C15H10O8

Molecular Weight :318.24     

CAS: 529-44-2

Part of plant used : Leaves , bark ;

Specification Standards : Myricetin 90%，98% (HPLC)

Clour:faint yellow powder

Function :

 1, Anti-oxidation; Myricetin is an inhibitor of cyclooxygenase 1 (COX-1), cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX);

2, Antagonic action on platelet activating factor (PAF), demonstrating pharmacological actions such as anti-thrombus, anti-myocardia ischemia, improving the microcirculation and prophylaxis of artery cirrhosis;

3, Adjusting cholesterol level; In vitro research suggests that myricetin in high concentration is capable of modifying LDL cholesterol in a manner that enhances its uptake by white blood cells.

4, Decreasing blood sugar; It can be used as food additive for diabetics;

5, Protecting liver;

6, Anti-inflammation and anti-infection;

7. Acting as inhibitor of matrix metalloproteinase; It can be used for prevention and treatment of cardiovascular disease and tumor;

8. A good dyeing agent.

Distribution

Myricetin is found in several foods such as walnuts, onions, berries, herbs and red grapes.

Properties

Myricetin exerts a wide variety of biological effects, including antioxidant and free radical-scavenging activities. Reports indicate that myricetin has anti-cancer and anti-inflammatory properties and may improve bone-health.

Anticancer

Myricetin has strong anticancer and antimutagernic properties, but it has been shown to promote mutagenesis with the use of the Ames Test. Although the anticancer property of myricetin has been attributed mainly to its antioxidant action, it has additional protective mechanisms.

Anti-inflammatory

Myricetin has been shown to inhibit the expression of tumor necrosis factor-alpha, a cytokine that promotes the inflammatory response and is involved in inflammatory diseases. Myricetin glucuronide is an inhibitor of lipoxygenase 5-LOX and cyclooxygenases COX-1 and Cox-2.

Heart health

Myricetin and other flavonoids may improve heart health by prevening LDL oxidation and reducing the uptake of oxidized LDL by macrophages.

Diabetes

Studies showed that myricetin inhibits the uptake of methylglucose by adipocytes, reduces oxidative injury in diabetes related bone diseases and reduces glucose plasma level in diabetic rats.

Brain health

Myricetin may offer benefits to person with brain diseases such as Parkinson and Alzheimers. Myricetin inhibits ROS production caused by glutamate and reduces glutamate-induced activation of caspase-3. Myricetin restored dopamine level in laboratory animals with induced Parkinsonism. Myricetin may also inhibit beta-amyloid fibril formation in Alzheimer patients.