成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> journal list >> ACS Applied Bio Materials >>article
ACS Applied Bio Materials

ACS Applied Bio Materials

IF: 4.59
Download PDF

Current Applications of Polycaprolactone as a Scaffold Material for Heart Regeneration

Published:27 May 2022 DOI: 10.1021/acsabm.2c00174
Phillip R. Schmitt, Kiera D. Dwyer and Kareen L. K. Coulombe*, 

Abstract

Despite numerous advances in treatments for cardiovascular disease, heart failure (HF) remains the leading cause of death worldwide. A significant factor contributing to the progression of cardiovascular diseases into HF is the loss of functioning cardiomyocytes. The recent growth in the field of cardiac tissue engineering has the potential to not only reduce the downstream effects of injured tissues on heart function and longevity but also re-engineer cardiac function through regeneration of contractile tissue. One leading strategy to accomplish this is via a cellularized patch that can be surgically implanted onto a diseased heart. A key area of this field is the use of tissue scaffolds to recapitulate the mechanical and structural environment of the native heart and thus promote engineered myocardium contractility and function. While the strong mechanical properties and anisotropic structural organization of the native heart can be largely attributed to a robust extracellular matrix, similar strength and organization has proven to be difficult to achieve in cultured tissues. Polycaprolactone (PCL) is an emerging contender to fill these gaps in fabricating scaffolds that mimic the mechanics and structure of the native heart. In the field of cardiovascular engineering, PCL has recently begun to be studied as a scaffold for regenerating the myocardium due to its facile fabrication, desirable mechanical, chemical, and biocompatible properties, and perhaps most importantly, biodegradability, which make it suitable for regenerating and re-engineering function to the heart after disease or injury. This review focuses on the application of PCL as a scaffold specifically in myocardium repair and regeneration and outlines current fabrication approaches, properties, and possibilities of PCL incorporation into engineered myocardium, as well as provides suggestions for future directions and a roadmap toward clinical translation of this technology.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Polycaprolactone 24980-41-4 C6H10O2 249 suppliers $37.68-$564.00
TRYPSIN INHIBITOR 12786-39-9 56 suppliers Inquiry

Similar articles

IF:2.6

Biological properties of polycaprolactone and barium titanate composite in biomedical applications.

Science Progress Sabreen Waleed Ibrahim,?Thekra Ismael Hamad,etc Published: 1 October 2023
IF:6.8

Neopentyl Glycol as a Scaffold to Provide Radiohalogenated Theranostic Pairs of High In Vivo Stability

Journal of Medicinal Chemistry Hiroyuki Suzuki*, Yuta Kaizuka,etc Published: 28 October 2021
IF:4.6

Paraffin wax as self-sealing insulation material of seasonal sensible heat storage systems-A laboratory study.

ACS Applied Bio Materials Christoph Bott, Ingo Dressel,etc Published: 29 July 2020