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ACS Applied Energy Materials

ACS Applied Energy Materials

IF: 5.4
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Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.

Published:21 July 2021 DOI: 10.3390/ph14080702 PMID: 34451799
Diana I S P Resende, Marta Salvador Ferreira, José Manuel Sousa-Lobo, Emília Sousa, Isabel Filipa Almeida

Abstract

Sensitive skin is characterized by symptoms of discomfort when exposed to environmental factors. Peptides are used in cosmetics for sensitive skin and stand out as active ingredients for their ability to interact with skin cells by multiple mechanisms, high potency at low dosage and the ability to penetrate the stratum corneum. This study aimed to analyze the composition of 88 facial cosmetics for sensitive skin from multinational brands regarding usage of peptides, reviewing their synthetic pathways and the scientific evidence that supports their efficacy. Peptides were found in 17% of the products analyzed, namely: acetyl dipeptide-1 cetyl ester, palmitoyl tripeptide-8, acetyl tetrapeptide-15, palmitoyl tripeptide-5, acetyl hexapeptide-49, palmitoyl tetrapeptide-7 and palmitoyl oligopeptide. Three out of seven peptides have a neurotransmitter-inhibiting mechanism of action, while another three are signal peptides. Only five peptides present evidence supporting their use in sensitive skin, with only one clinical study including volunteers having this condition. Noteworthy, the available data is mostly found in patents and supplier brochures, and not in randomized placebo-controlled studies. Peptides are useful active ingredients in cosmetics for sensitive skin. Knowing their efficacy and synthetic pathways provides meaningful insight for the development of new and more effective ingredients.

Substances (9)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Palmitoyl Tripeptide-5 623172-56-5 C35H66F3N5O7 272 suppliers $32.00-$297.00
Palmitoyl tetrapeptide-7 221227-05-0 C34H62N8O7 268 suppliers Inquiry
Palmitoyl Tripeptide-8 936544-53-5 C37H61N9O4 179 suppliers Inquiry
Acetyl tetrapeptide 15 928007-64-1 C34H39N5O6 106 suppliers Inquiry
Acetyl Dipeptide-1 cetyl ester 196604-48-5 C33H57N5O5 100 suppliers Inquiry
Acetyl Hexapeptide-46 1459205-54-9 33 suppliers Inquiry
PALMITOYL OLIGOPEPTIDE 21 suppliers Inquiry
Palmitoyl Tripeptide-5 623172-55-4 C33H65N5O5 15 suppliers Inquiry
ACETYL DIPEPTIDE-1 CETYL ESTER 11 suppliers Inquiry

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