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International Journal of Molecular Sciences

International Journal of Molecular Sciences

IF: 4.9
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The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment.

Published:18 June 2021 DOI: 10.3390/ijms22126564 PMID: 34207344
Barbara Ko?odziejska, Natalia St?pień, Joanna Kolmas

Abstract

Osteoporosis is a chronic disease characterized by low bone mass caused by increased bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or anabolic drugs, which usually have a unidirectional effect, i.e., they inhibit the activity of osteoclasts or stimulate the effect of osteoblasts. Strontium ranelate is an anti-osteoporosis drug with a unique mechanism of action (used primarily in postmenopausal women). Unlike other medicines, it has a multidirectional effect on bone tissue, intensifying osteoblastogenesis while inhibiting osteoclastogenesis. It turns out that this effect is demonstrated by strontium ions, an element showing physical and chemical similarity to calcium, the basic element that builds the mineral fraction of bone. As a result, strontium acts through the calcium-sensing receptor (CaSR) receptor in bone tissue cells. In recent years, there has been a significant increase in interest in the introduction of strontium ions in place of calcium ions in ceramics used as bone replacement materials for the treatment of bone fractures and defects caused by osteoporosis. The aim of this study was to summarize current knowledge about the role of strontium in the treatment of osteoporosis, its effects (in various forms), and the ways in which it is administered.

Substances (5)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Strontium ranelate 135459-87-9 C12H12N2O8SSr 410 suppliers $5.00-$1871.10
STRONTIUM 7440-24-6 Sr 159 suppliers $32.65-$4040.00
STRONTIUM STANNATE 12143-34-9 O3SnSr 25 suppliers Inquiry
α-KETOLEUCINE CALCIUM 22 suppliers Inquiry
Calcium Sensing Receptor (CASR) Ca 1 suppliers Inquiry

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