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ACS Applied Bio Materials

ACS Applied Bio Materials

IF: 4.59
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Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda.

Published:1 March 2018 DOI: 10.1097/MPG.0000000000001817 PMID: 29077645
Kristina I Rother, Allison C Sylvetsky, Peter J Walter, H Martin Garraffo, David A Fields

Abstract

Objective: The aim of this study was to determine sucralose and acesulfame-potassium (ace-K) pharmacokinetics in breast milk following maternal ingestion of a diet soda.

Methods: Thirty-four exclusively breast-feeding women (14 normal-weight, 20 obese) consumed 12 ounces of Diet Rite Cola, sweetened with 68-mg sucralose and 41-mg ace-K, before a standardized breakfast meal. Habitual non-nutritional sweeteners intake was assessed via a diet questionnaire. Breast milk was collected from the same breast before beverage ingestion and hourly for 6 hours.

Results: Owing to one mother having extremely high concentrations, peak sucralose and acesulfame-potassium concentrations following ingestion of diet soda ranged from 4.0 to 7387.9?ng/mL (median peak 8.1?ng/mL) and 299.0 to 4764.2?ng/mL (median peak 945.3?ng/mL), respectively.

Conclusions: Ace-K and sucralose transfer into breast milk following ingestion of a diet soda. Future research should measure concentrations after repeated exposure and determine whether chronic ingestion of sucralose and acesulfame-potassium via the breast milk has clinically relevant health consequences.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Sucralose 56038-13-2 C12H19Cl3O8 841 suppliers $5.00-$6750.00
Acesulfame potassium 55589-62-3 C4H4KNO4S 476 suppliers $7.00-$1593.90

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