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International Journal of Toxicology

International Journal of Toxicology

IF: 1.2
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Final amended report on the safety assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid.

Published:1 July 2009 DOI: 10.1177/1091581809339890 PMID: 19636068
Christina L Burnett, Wilma F Bergfeld, Donald V Belsito, Curtis D Klaassen, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen

Abstract

This safety assessment includes Ammonium and Glyceryl Thioglycolate and Thioglycolic Acid Butyl, Calcium, Ethanolamine, Ethyl, Isooctyl, Isopropyl, Magnesium, Methyl, Potassium, and Sodium Thioglycolate, as used in cosmetics. Thioglycolates penetrate skin and distribute to the kidneys, lungs, small intestine, and spleen; excretion is primarily in urine. Thioglycolates were slightly toxic in rat acute oral toxicity studies. Thioglycolates are minimal to severe ocular irritants. Thioglycolates can be skin irritants in animal and in vitro tests, and can be sensitizers. A no-observable-adverse-effect level for reproductive and developmental toxicity of 100 mg/kg per day was determined using rats. Thioglycolates were not mutagenic, and there was no evidence of carcinogenicity. Thioglycolates were skin irritants in some clinical tests. Clinically significant adverse reactions to these ingredients used in depilatories are not commonly seen, suggesting current products are formulated to be practically nonirritating under conditions of recommended use. Formulators should take steps necessary to assure that current practices are followed.

Substances (16)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Thioglycolic acid 68-11-1 C2H4O2S 463 suppliers $12.00-$6413.60
Sodium thioglycolate 367-51-1 C2H5NaO2S 451 suppliers $25.65-$1050.00
Methyl thioglycolate 2365-48-2 C3H6O2S 413 suppliers $19.00-$4324.54
Ethyl Thioglycolate 623-51-8 C4H8O2S 282 suppliers $7.00-$1189.10
Ammonium thioglycolate 5421-46-5 C2H7NO2S 257 suppliers $19.00-$6415.91
Calcium thioglycolate 814-71-1 C4H6CaO4S2 197 suppliers Inquiry
ISOOCTYL THIOGLYCOLATE 25103-09-7 C10H20O2S 152 suppliers $14.14-$334.00
POTASSIUM THIOGLYCOLATE 34452-51-2 C2H3KO2S 107 suppliers Inquiry
Glyceryl monothioglycolate 30618-84-9 C5H10O4S 91 suppliers Inquiry
THIOGLYCOLIC ACID N-BUTYL ESTER 10047-28-6 C6H12O2S 78 suppliers $14.00-$621.69

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