Chemoselective TBS deprotection of primary alcohols by means of pyridinium tribromide (Py·Br3) in MeOH
Published:25 August 2008
DOI: 10.1016/j.tetlet.2008.06.072
Dionicio Martinez-Solorio, Michael P. Jennings
Abstract
A catalytic amount of pyridinium tribromide (Py·Br3) in MeOH chemoselectively deprotects primary TBS ethers in the presence of a variety of other protecting and common functional groups in modest to excellent yields when performed at 0?°C.