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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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A multifunctional bacterial cellulose-based dressing modified by quaternized chitosan and grafted protocatechuic acid for diabetic ulcer

Published:11 December 2024 DOI: 10.1016/j.ijbiomac.2024.138673 PMID: 39672428
Haiyong Ao,?Xiao Han,?Chen Zhou,?Shiqing Zhou,?Maohu Wang,?Xiaowei Xun,?Xidong Wu,?Yaqiang Li,?Jiajia Zong,?Yizao Wan

Abstract

Herein, we developed a multifunctional bacterial cellulose-based dressing (PHBC) modified by quaternized chitosan (HACC) along with protocatechuic acid (PA), through in situ biosynthesis combined with covalent immobilization. The obtained PHBC dressing maintained the excellent physicochemical characteristics of BC, such as high porosity (above 76?%); high water absorption ratio, >80?% of water absorption rate (approximately 30?g/g) has completed in half an hour; favorable hydrophilicity with contact angle of about 50° and excellent flexibility. The introduction of PA-grafted HACC endows exhibited outstanding antibacterial properties against, anti-inflammatory performance and antioxidant capacity. Furthermore, PHBC II, with the reaction solubility of PA was 3?mg/mL, could promote NIH3T3 and HUVECs proliferation and spread. In vivo experiments further verified that PHBC II can effectively promote new granulation tissue hyperplasia and collagen deposition and expression around diabetic ulcers, reduce the inflammatory phenomenon around the wound, and promote the internal capillaries of the wound. The repair and regeneration of the network can promote better and faster wound healing. These results illustrate that the PHBC functional dressing has an important reference value for the clinical treatment of diabetic ulcers.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
N-Hydroxysuccinimide 6066-82-6 C4H5NO3 885 suppliers $5.00-$3348.80
Chitosan 9012-76-4 C6H11NO4X2 860 suppliers $14.00-$1125.56

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