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    ChemicalBook >> journal list >> International Journal of Biological Macromolecules >>article
    International Journal of Biological Macromolecules

    International Journal of Biological Macromolecules

    IF: 7.7
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    Dual peptide-coordinated dynamic hydrogel with antibacterial and proangiogenic activities for infected skin wounds

    Published:4 December 2024 DOI: 10.1016/j.ijbiomac.2024.138349 PMID: 39638200
    Li Ni,?Xiaoyu Zhang,?Jia Gao,?Junjiang Yue,?Linlin Zhang,?Guoqing Pan

    Abstract

    Infected skin wounds represent a class of significant clinical challenges due to their complexity and the risk of delayed healing. Developing an effective wound dressing capable of promoting tissue regeneration while addressing infections is crucial. In this study, we designed a dual peptide-coordinated dynamic hydrogel with both antibacterial and proangiogenic properties, specifically tailored for treating infected skin wounds. The dynamic hydrogel was constructed using gelatin, a natural biomacromolecule with high biocompatibility, as the base material. Two functional peptides, the antibacterial melittin and angiogenic peptide, were incorporated to enhance both infection control and tissue repair. Hydrogelation was achieved through coordination interactions between gold (Au) ions and sulfhydryl groups, endowing the hydrogel with dynamic properties. The excellent biocompatibility, antibacterial efficacy and angiogenic capability of hydrogel allow it to provide structural support for wound healing while promoting cell proliferation and migration. By eradicating bacteria and stimulating new blood vessel formation, it accelerates the healing of infected wounds. Additionally, its injectability and self-healing properties make it suitable for treating irregularly shaped and deep wounds. This dual-functional hydrogel may offer a promising and minimally invasive treatment option for infected skin wounds, combining high biological safety with simplified surgical procedures.

    Substances (12)

    Materials
    Procduct Name CAS Molecular Formula Supplier Price
    Sodium chloride 7647-14-5 ClNa 1242 suppliers $5.00-$6678.62
    Sodium hydroxide 1310-73-2 NaOH 1240 suppliers $14.00-$16472.00
    Ethylenediaminetetraacetic acid 60-00-4 C10H16N2O8 1202 suppliers $10.00-$6397.62
    Ethanol 64-17-5 C2H6O 840 suppliers $10.00-$17310.00
    Agar 9002-18-0 C14H24O9 598 suppliers $14.00-$4338.01
    Xylene 1330-20-7 C8H10 561 suppliers $9.00-$6709.97
    Triton X-100 9002-93-1 (C2H4O)nC14H22O 558 suppliers $18.00-$610.00
    Yeast extract 8013-01-2 n.a. 374 suppliers $31.00-$7970.00
    Propidium iodide 25535-16-4 C27H34IN4+ 328 suppliers $29.00-$1780.00
    PARAFFIN 8020-83-5 NULL 100 suppliers $36.80-$497.54

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