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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Dual peptide-coordinated dynamic hydrogel with antibacterial and proangiogenic activities for infected skin wounds

Published:4 December 2024 DOI: 10.1016/j.ijbiomac.2024.138349 PMID: 39638200
Li Ni,?Xiaoyu Zhang,?Jia Gao,?Junjiang Yue,?Linlin Zhang,?Guoqing Pan

Abstract

Infected skin wounds represent a class of significant clinical challenges due to their complexity and the risk of delayed healing. Developing an effective wound dressing capable of promoting tissue regeneration while addressing infections is crucial. In this study, we designed a dual peptide-coordinated dynamic hydrogel with both antibacterial and proangiogenic properties, specifically tailored for treating infected skin wounds. The dynamic hydrogel was constructed using gelatin, a natural biomacromolecule with high biocompatibility, as the base material. Two functional peptides, the antibacterial melittin and angiogenic peptide, were incorporated to enhance both infection control and tissue repair. Hydrogelation was achieved through coordination interactions between gold (Au) ions and sulfhydryl groups, endowing the hydrogel with dynamic properties. The excellent biocompatibility, antibacterial efficacy and angiogenic capability of hydrogel allow it to provide structural support for wound healing while promoting cell proliferation and migration. By eradicating bacteria and stimulating new blood vessel formation, it accelerates the healing of infected wounds. Additionally, its injectability and self-healing properties make it suitable for treating irregularly shaped and deep wounds. This dual-functional hydrogel may offer a promising and minimally invasive treatment option for infected skin wounds, combining high biological safety with simplified surgical procedures.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium chloride 7647-14-5 ClNa 1214 suppliers $5.00-$6678.62
Sodium hydroxide 1310-73-2 NaOH 1210 suppliers $14.00-$16472.00
Ethylenediaminetetraacetic acid 60-00-4 C10H16N2O8 1170 suppliers $10.00-$6397.62
Ethanol 64-17-5 C2H6O 806 suppliers $10.00-$17310.00
Agar 9002-18-0 C14H24O9 577 suppliers $14.00-$4338.01
Xylene 1330-20-7 C8H10 543 suppliers $9.00-$6709.97
Triton X-100 9002-93-1 (C2H4O)nC14H22O 531 suppliers $18.00-$610.00
Yeast extract 8013-01-2 n.a. 355 suppliers $31.00-$7970.00
Propidium iodide 25535-16-4 C27H34IN4+ 295 suppliers $29.00-$1780.00
PARAFFIN 8020-83-5 NULL 101 suppliers $36.80-$497.54

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