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Engineering Nano‐Pills to Inhibit Ovarian Cancer Proliferation and Migration through a Combination of Chemical/Nucleic Acid Therapy

Published:22 November 2024 DOI: 10.1002/smll.202408095
Chao Jia, Qirui Liu, Man Zhang, Cong Han, Xuantong Luo, Yu Zhou, Yi Liu, Liyun Zhang

Abstract

Ovarian cancer (OC) is the most fatal of all gynecological malignancies, presenting a significant threat to women's health. Its treatment is complicated by severe dose-dependent chemotherapy toxicity, drug resistance, and tumor migration. Herein, an intelligent combination strategy of chemotherapy and nucleic acid therapy, named ApMEmiR&D is developed. This integrated system consists of three parts: the nano-pill, the protective membrane, and the navigation element. Nano-pills are nanospheres assembled from miRNA and doxorubicin (DOX) with the help of ferrous ions (Fe2+). The protective membrane is derived from tumor-associated macrophages (TAMs membrane) originating from the primary tumor microenvironment (TME). The navigation element is the cholesterol-conjugated AS1411 aptamer. The resulting ApMEmiR&D nanoparticles exhibit uniform size, a well-defined nanosphere structure, robust serum stability, and ultra-high drug loading efficiency and capacity. The system can efficiently accumulate in the tumor, allowing for the synergistic inhibition of tumor growth and metastasis without apparent systemic toxicity. The results demonstrate the homing effect of tumor microenvironment-derived macrophage cell membrane and the targeting effect of aptamer, leading to precise drug targeting and immune compatibility, thereby enhancing therapeutic efficacy. The success of this strategy paves the way for metastasis inhibition and targeted cancer therapy.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Colchicine 64-86-8 C22H25NO6 723 suppliers $16.00-$3980.00
Ferrous chloride 7758-94-3 Cl2Fe 329 suppliers $10.00-$1470.46
Chlorpromazine 50-53-3 C17H19ClN2S 132 suppliers $49.00-$1334.03
FETUIN 9014-81-7 NULL 66 suppliers $37.07-$4380.00

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