Xenon
Feb 21,2022
Physical properties
Xenon has a blood/gas partition coefficient of 0.14–0.2, which is lower than that of nitrous oxide (0.47) and therefore provides rapid induction of and recovery from anaesthesia. Xenon is more potent than nitrous oxide, with a MAC of 70%. It does not undergo biotransformation, and it is harmless to the ozone layer.
Systemic effects
Studies so far have found no cardiorespiratory adverse effects or reduction in local organ perfusion; in fact, to date it has demonstrated both cardio- and neuroprotective properties through a variety of mechanisms. It is not irritating to the respiratory tract. Xenon is a competitive inhibitor of the 5-HT3 receptor and is therefore thought to reduce the incidence of PONV.
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