Melatonine, a hormone naturally produced in the body, governs the rhythm of day and night, as well as the sleep-wake cycles. Typically synthesized in laboratories, melatonine supplements serve various purposes.

Utilization of Melatonine

The onset of darkness prompts the body to increase melatonine production, facilitating sleep initiation. Conversely, exposure to light reduces melatonine levels, promoting wakefulness. Individuals experiencing sleep difficulties often exhibit insufficient melatonine levels, prompting the consideration of melatonin supplementation to aid in improving sleep quality.

Melatonine is primarily utilized by individuals seeking relief from insomnia and to enhance sleep quality under varied circumstances, including combating jet lag. Additionally, it is employed in addressing conditions such as depression, chronic pain, and dementia, among others. However, scientific evidence substantiating its efficacy for many of these applications remains inconclusive. Furthermore, there is insufficient empirical support for the use of melatonine in treating COVID-19.

Safety Dosage

Melatonine administration in adults typically ranges up to 8 mg orally per day for a duration of up to 6 months. For children, the usual dosage is up to 3 mg orally daily for a maximum period of 3 months.

Various formulations of melatonine supplements are available, including slow-release and fast-release options. Certain products are designed for sublingual or buccal absorption, facilitating faster onset. Melatonine is also incorporated into creams, gargles, and gels. Consultation with a healthcare professional is advised to determine the most suitable product and dosage for a specific condition.

Experts recommend initiating melatonin supplementation with 1-2 milligrams taken 30 minutes before bedtime. For some individuals, doses lower than 1-2 milligrams may suffice. If initial doses prove ineffective in promoting sleep onset, gradual dose escalation is recommended until a therapeutic effect is observed.

Although there is no definitive upper limit for melatonine, experts generally advocate for a maximum dosage of 10 milligrams in adults. Individuals with kidney or liver impairments may metabolize melatonine more slowly, necessitating a lower upper limit.