Methyltestosterone (17-Methyltestosterone), whose chemical name is 17b-hydroxy-17a-methylandrost-4-en-3-one, is a hormone steroid drug developed by the former Ciba company in Switzerland and has been marketed in many countries. Clinically treating male sexual dysfunction, anorchidism and cryptorchidism; gynecological diseases, such as menorrhagia, endometriosis; senile osteoporosis and aplastic anemia in children, etc. As an androgen drug, methyltestosterone is clinically suitable for promoting the development of male sexual organs and auxiliary sexual characteristics and maintaining their normal functions; female functional uterine bleeding and migratory breast cancer.

Efficacy

Methyltestosterone (17-Methyltestosterone)can promote the development and maturity of male sexual organs and side characteristics; fight estrogen, inhibit endometrial growth and ovarian and pituitary function; promote protein synthesis and bone formation, stimulate bone marrow hematopoietic function, and increase red blood cells and hemoglobin . It is clinically used for male hypogonadism, anorchidism, cryptic disease, menorrhagia, uterine fibroids, endometriosis, senile osteoporosis, and aplastic anemia in children.

Pharmacokinetics

This product is absorbed through the gastrointestinal tract and oral mucosa. The plasma concentration reaches a peak 1-2 hours after oral administration of 10 mg, and the T1/2 is about 2.5-3.5 hours. The metabolism in the body is slower than that of testosterone. The effect of sublingual administration is 2 times higher than oral administration. Since oral metabolism is inactivated by the liver, it is better to take it under the tongue, and the dose can be reduced by half. Its metabolites (mostly combined) and about 5%-10% of the administered dose are excreted in the urine in their original form.

Precautions

1) Pregnant women, patients with prostate cancer and those who are allergic to this product are contraindicated.

2) Use with caution in patients with poor heart, liver, and kidney dysfunction, prostate hyperplasia, and hypertension.

3) Long-term use in children can seriously affect growth and development.

Interactions

1) Combined use with barbiturates can increase the intrahepatic metabolism of this product and weaken its effect.

2) This product can enhance the effect of thyroid hormone.

3) Combined use with adrenal cortex hormones can aggravate edema.

4) Combined use with anticoagulants can enhance the efficacy of the latter and increase the risk of bleeding.