Abiraterone is used in combination with prednisone to treat a certain type of prostate cancer that has spread to other parts of the body. Abiraterone is in a class of medications called androgen biosynthesis inhibitors. It works by decreasing the amount of certain hormones in the body.

Usage

Abiraterone comes as a tablet to take by mouth on an empty stomach with water, 1 hour before or 2 hours after eating any food. It is usually taken once or twice a day. Take abiraterone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take abiraterone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole with water; do not split, chew, or crush them.

Continue to take abiraterone even if you feel well. Do not stop taking abiraterone or prednisone without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Special precautions

Before taking abiraterone,tell your doctor and pharmacist if you are allergic to abiraterone, any other medications, or any of the ingredients in abiraterone tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: dextromethorphan; certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); ketoconazole; nefazodone; pioglitazone (Actos); rifabutin (Mycobutin); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); rifapentine (Priftin); and thioridazine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with abiraterone, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

tell your doctor if you have an infection, a low level of potassium in your blood, or are experiencing unusual stress, have had a recent heart attack, or if you have or have ever had adrenal or pituitary gland problems, heart failure, an irregular heartbeat, including QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death), high blood pressure, or heart or liver disease.
you should know that abiraterone is only for use in men. Women should not take this medication, especially if they are or may become pregnant or are breastfeeding. If taken by pregnant women, abiraterone may harm the fetus. Women who are, could become, or may be pregnant should not touch abiraterone tablets without protective gloves.

Side effects

Abiraterone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
joint swelling or pain
groin pain
hot flashes (a sudden wave of mild or intense body heat)
diarrhea
heartburn
cough
difficulty falling asleep or staying asleep
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
dizziness
feeling faint or lightheaded
headache
confusion
fast or irregular heartbeats
muscle weakness or aches
leg pain
swelling of the hands, feet, ankles, or lower legs
rash
unusual bruising or bleeding
extreme tiredness
lack of energy
nausea