尼達(dá)尼布

中文名稱:尼達(dá)尼布

中文同義詞:尼達(dá)尼布雜質(zhì)(A-D);尼達(dá)尼布乙烷磺酸鹽;尼達(dá)尼布雜質(zhì)對(duì)照品;(3Z)-2,3-二氫-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亞甲基]-2-氧代-1H-吲哚-6-甲酸甲酯;尼達(dá)尼布5G;尼達(dá)尼布雜質(zhì)系列;INTEDANIBBASE

英文名稱:Nintedanib

英文同義詞:Nintedanib-016;Nintedanib(Intedanib);methyl(3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylateNintedanib(BIBF1120);Vargatef(nintedanib);3-[(4-{Methyl-[2-(4-methyl-piperazin-1-yl)-acetyl]-amino}-phenylamino)-phenyl-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylicacidmethylester;3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone;Nintedanib,FreeBase,>99%;methyl(3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

CAS號(hào):656247-17-5

分子式:C31H33N5O4

分子量:539.62482

特發(fā)性肺纖維化（IPF）治療藥物：尼達(dá)尼布是由德國(guó)勃林格殷格翰公司研發(fā)的一種口服給藥的三重酪氨酸激酶抑制劑，靶點(diǎn)包括血小板源生長(zhǎng)因子(PDGF)、血管內(nèi)皮生長(zhǎng)因子(VEGF)和堿性纖維母細(xì)胞生長(zhǎng)因子(bFGF)，也可抑制MAPK和Akt激活。目前主要用于腫瘤治療，如結(jié)腸直腸癌、卵巢癌、多發(fā)性骨髓瘤等。針對(duì)呼吸系統(tǒng)疾病的研究主要圍繞晚期非小細(xì)胞肺癌(NSCLC)和特發(fā)性肺間質(zhì)纖維化(IPF)的臨床治療開(kāi)展。