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醋酸特利加壓素,Terlipressin Acetate
  • 醋酸特利加壓素,Terlipressin Acetate

醋酸特利加壓素

價(jià)格 詢(xún)價(jià)
包裝 5kg 10kg
最小起訂量 5kg
發(fā)貨地 浙江
更新日期 2021-03-26

產(chǎn)品詳情

中文名稱(chēng):醋酸特利加壓素英文名稱(chēng):Terlipressin Acetate
CAS:14636-12-5純度規(guī)格: 99.5%
產(chǎn)品類(lèi)別: 原料藥與中間體
備注: US-DMF Pre-assigned
2021-03-26 醋酸特利加壓素 Terlipressin Acetate 5kg/RMB;10kg/RMB 99.5% 原料藥與中間體


Product Name: Terlipressin Acetate
Synonyms: 36T125; D06672; Q324147; DB02638; HS-2028; CS-5769; EX-A3116; HY-12554; SC-47098; J-008213; Variquel; Remestyp; LS-161411; GTPL11241; CCG-270662; 14636-12-5; Glypressin; CHEBI:135905; Tox21_113374; SCHEMBL22699; TERLIPRESSIN; CHEMBL2135460; DTXSID7048952; Lucassin (TN); AKOS015994637; Terlipressina; Terlipressine; Glycylpressin; C52H74N16O15S2; CAS-14636-12-5; TerlipressinuM; NCGC00185754-01; EINECS 238-680-8; DSSTox_CID_28878; DSSTox_RID_83146; DSSTox_GSID_48952; Thymosin α1 Acetate; Thymosin al Acetate; Terlipressin Acetate; Terlipressin [BAN:INN]; Terlipressin (USAN/INN); Terlipressine [INN-French]; Terlipressinum [INN-Latin]; Terlipressina [INN-Spanish]; Terlipressin [USAN:INN:BAN]; Terlipressin Diacetate Salt; Terlipressin acetate, >=98%; Triglycyl-8-lysine-vasopressin; 1-Triglycyl-8-lysine Vasopressin; 130: PN: WO2010033207 SEQID: 171 claiMed protein; N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin; H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2; Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9)
CAS Registry number: 14636-12-5
EINECS238-680-8
Molecular Formula: C52H74N16O15S2
Boiling Point: 1824 °C at 760 mmHg
Flash Point: 1056.9 °C
Refractive index: 1.664
Density: 1.46 
Appearance: White powder

Pharmacological effects: Terlipressin is a novel long-acting synthetic vasopressin reagent,its chemical name is three glycyl lysine vasopressin, it is a prodrug, itself has no activity ,in vivo  , it removes three glycyl residues in its N-terminus by aminopeptidase, and slowly "releases" the active lysine vasopressin. It is this "slow release" mechanism that makes it maintain the smooth muscle contraction up to 10 hours after a single administration, whereas the same dose of vasopressin, it can maintain its activity for 20-40 minutes. On the other hand,because of the slow digestion,  lysine vasopressin in the circulation cannot reach toxic levels, and usage of  terlipressin is safer.

Pharmacological effect of terlipressin is splanchnic vascular smooth muscle contraction, and reduction of visceral blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal vein blood flow,and reducing portal pressure, on the other hand it may also reduce plasma renin concentration, thereby increasing the renal blood flow in patients with hepatorenal syndrome, to improve kidney function, and increase urine output. Terlipressin is currently the only drug which is able to increase mortality in patients with esophageal varices bleeding , it is previously mainly used in clinical for the treatment of variceal bleeding, in addition,terlipressin now has also been successfully used for liver and kidney integrated syndrome and refractory shock, it is also likely to play a useful role in the cardiopulmonary resuscitation . Compared with vasopressin, it has a lasting effect, and it does not cause dangerous complications, including promoting  fibrinolysis and severe complications in the cardiovascular systems, and the use of it is simple (available intravenous injection), it is more suitable for rescue and treatment of emergent and critical  patients.

Uses: N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is also used in the treatment of acute variceal bleeding.


關(guān)鍵字: 原料藥與中間體;

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成立日期 2003-08-13 (22年) 注冊(cè)資本 1000萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以?xún)?nèi)
主營(yíng)行業(yè) 中間體,醫(yī)藥原料 經(jīng)營(yíng)模式 貿(mào)易
  • 浙江凱發(fā)工貿(mào)有限公司
非會(huì)員
  • 公司成立:22年
  • 注冊(cè)資本:1000萬(wàn)人民幣
  • 企業(yè)類(lèi)型:民營(yíng)
  • 主營(yíng)產(chǎn)品:多種原料藥和中間體
  • 公司地址:西湖區(qū)蓮花峰路12號(hào)
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