異丙安替比林簡(jiǎn)介藥理作用應(yīng)用不良反MSDS用途與合成方法異丙安替比林價(jià)格(試劑級(jí))上下游產(chǎn)品信息專題中文名稱:異丙安替比林中文同義詞:異丙安替比林;異丙安替比林溶液,100PPM;異丙基安替比林標(biāo)準(zhǔn)品;1,5-二甲基-4-異丙基-2-苯基-1,2-二氫-3H-吡唑-3-酮;2,2-二甲基-3-亞甲基降茨烷;3,3-二甲基-2-亞甲基降莰烷;1,2-二氫-1,5-二甲基-4-異丙基-2-苯基-3H-吡唑-3-酮;4-異丙基安替比林英文名稱:Propyphenazone英文同義詞:1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on;3-Pyrazolin-5-one,4-isopropyl-2,3-dimethyl-1-phenyl-;4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one;4-isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on;4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one;4-Isopropyl-2,3-dimethyl-5-oxo-1-phenyl-3-pyrazoline;4-isopropyl-antipyrinCAS號(hào):479-92-5分子式:C14H18N2O分子量:230.31EINECS號(hào):207-539-2相關(guān)類別:吡唑;中藥對(duì)照品;標(biāo)準(zhǔn)品;Aromatics;Heterocycles;Intermediates&FineChemicals;ActivePharmaceuticalIngredients;API's;PharmaceuticalsMol文件:479-92-5.mol異丙安替比林性質(zhì)熔點(diǎn)102-105°C沸點(diǎn)372.3°C(roughestimate)密度1.0371(roughestimate)折射率1.5500(estimate)儲(chǔ)存條件Refrigerator溶解度Slightlysolubleinwater,freelysolubleinethanol(96percent)andinmethylenechloride.形態(tài)neat酸度系數(shù)(pKa)1.46±0.65(Predicted)水溶解性743.6g/L(25.35ºC)Merck14,7871BRN204533穩(wěn)定性Stable.Incompatiblewithstrongoxidizingagents.CAS數(shù)據(jù)庫(kù)479-92-5(CASDataBaseReference)NIST化學(xué)物質(zhì)信息Propyphenazone(479-92-5)EPA化學(xué)物質(zhì)信息3H-Pyrazol-3-one,1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-(479-92-5)異丙安替比林用途與合成方法簡(jiǎn)介異丙安替比林，又名丙非那宗、苯甲丙吡唑酮，為安替比林的衍生物，白色或者微黃色結(jié)晶性粉末，微溶于水，溶于乙醚，易溶于乙醇、二氯甲烷。屬吡唑酮類解熱鎮(zhèn)痛劑與安替比林、氨基比林有類似的藥理作用，但毒性小。臨床用于解熱鎮(zhèn)痛，療效顯著。藥理作用異丙安替比林作用機(jī)理屬中樞性，解熱作用大體與安替比林、氨基比林相同，鎮(zhèn)痛、抗炎作用則略低，其作用與巴比妥并用時(shí)可增強(qiáng)，作用時(shí)間延長(zhǎng)，而毒性亦增加，對(duì)腸道平滑肌有松弛作用，其效力較罌粟減弱，而為氨基比林的4倍。本品很少單用，多與其他解熱、鎮(zhèn)痛、消炎藥組成復(fù)方而增強(qiáng)治療效果，與麻黃堿、咖啡因配合也有協(xié)同作用。應(yīng)用異丙安替比林類似安替比林，有解熱鎮(zhèn)痛作用。臨床用于發(fā)熱、頭痛、神經(jīng)痛、牙痛、痛經(jīng)等。不良反異丙安替比林不良反應(yīng)有皮疹、消化不良、虛脫等?；加羞策≌呱饔?。