中文名稱:PND-1186 VS-4718 | 英文名稱:PND-1186 VS-4718 |
CAS:1061353-68-1 | 保存條件: -20 ℃ |
純度規(guī)格: 98% min | 產(chǎn)品類別: API |
PND-1186, also known as SR-2156 and VS-4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 µM PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 µM PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. PND-1186 inhibited 4T1 breast carcinoma subcutaneous tumor growth correlated with elevated tumor cell apoptosis and caspase 3 activation.
成立日期 | 2011-08-02 (14年) | 注冊資本 | 200萬 |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 1000萬-5000萬 |
主營行業(yè) | 中間體,醫(yī)藥原料,醫(yī)藥中間體,原料藥 | 經(jīng)營模式 | 貿(mào)易,工廠,定制 |
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