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Anti-HDAC4(N-term) Monoclonal Antibody,Anti-HDAC4(N-term) Monoclonal Antibody
  • Anti-HDAC4(N-term) Monoclonal Antibody,Anti-HDAC4(N-term) Monoclonal Antibody

Anti-HDAC4(N-term) Monoclonal Antibody

價格 960.00 1600.00
包裝 50ul 100ul
最小起訂量 50ul
發(fā)貨地 北京
更新日期 2024-11-18
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產(chǎn)品詳情

中文名稱:Anti-HDAC4(N-term) Monoclonal Antibody英文名稱:Anti-HDAC4(N-term) Monoclonal Antibody
Gene ID: 9759Public Immunogen Range: Purified recombinant human HDAC4 protein fragments expressed in E.coli
Subcellular Locations: Cytoplasm NucleusSwiss Prot: P56524
保存: Store at -20°C. Avoid freeze / thaw cycles.別名: AHO3;BDMR;HA6116;HD4;HDAC-4;HDAC-A;HDACA
產(chǎn)品編號: K000010M儲存液: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
純化方法: Affinity purification蛋白分子量: 119kDa
交叉反應(yīng): Human克隆號: 4A3-H7-C6
克隆類型: Monoclonal Antibody免疫原: Purified recombinant human HDAC4 protein fragments expressed in E.coli
品牌: solarbio宿主: Mouse
稀釋比例: WB 1:1000.性狀: 液體
亞型: IgG2a應(yīng)用: WB IP
英文名稱: Anti-HDAC4(N-term) Monoclonal Antibody
2024-11-18 Anti-HDAC4(N-term) Monoclonal Antibody Anti-HDAC4(N-term) Monoclonal Antibody 50ul/960.00RMB;100ul/1600.00RMB 960.00

背景資料

Chromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p.HDAC4 is a class II histone deacetylase containing 1084 amino acid residues. HDAC4 has been shown to interact with NCoR. HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation. HDAC4 has also been shown to interact with other deacetylases such as HDAC3 as well as the corepressors NcoR and SMART.
關(guān)鍵字: Anti-HDAC4(N-term) Monoclonal Antibody;蛋白與免疫

公司簡介

北京索萊寶科技有限公司是一家集研發(fā)、生產(chǎn)、銷售、服務(wù)于一體的高科技生物企業(yè)。技術(shù)推廣;技術(shù)轉(zhuǎn)讓;技術(shù)咨詢;技術(shù)服務(wù);生物試劑技術(shù)開發(fā);銷售生物試劑盒、實驗室專用化學(xué)試劑、實驗室專用設(shè)備、辦公用品、化工產(chǎn)品(不含危險化學(xué)品)、計算機軟件及輔助設(shè)備;貨物進出口、技術(shù)進出口、代理進出口;委托加工生產(chǎn)生物制品、生化制品、化工產(chǎn)品(不含危險化學(xué)品);生產(chǎn)生物試劑盒;批發(fā)第一類醫(yī)療器械、第二類醫(yī)療器械;批發(fā)第三類醫(yī)療器械。
成立日期 2004-09-22 (21年) 注冊資本 1000萬元
員工人數(shù) 50-100人 年營業(yè)額 ¥ 500萬-1000萬
主營行業(yè) 分析化學(xué),生物化工,化學(xué)試劑,醫(yī)藥原料,儀器耗材 經(jīng)營模式 貿(mào)易,工廠,試劑
  • 北京索萊寶科技有限公司
VIP 9年
  • 公司成立:21年
  • 注冊資本:1000萬元
  • 企業(yè)類型:有限責任公司
  • 主營產(chǎn)品:tris,甘氨酸,瓊脂粉,潮霉素B,SDS,BSA
  • 公司地址:聯(lián)東U谷景盛南四街85A三層
詢盤

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