Species

Gene ID

Accession

Source

Length

MW

Tag

Mouse

14573

P48540

E. coli

134aa

29.9kDa

－

About this Antibody

Name

Recombinant Murine GDNF (Recombinant Murine Glial Cell-derived Neurotrophic Factor; rMuGDNF)；Recombinant Mouse GDNF ; 重組小鼠膠質細胞源性神經(jīng)營養(yǎng)因子

Synonyms

Astrocyte-derived trophic factor; ATF; ATF1; ATF2; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; glial cell line-derived neurotrophic factor; HFB1-GDNF; hGDNF; HSCR3

Purity

>95% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.2ng/ml, corresponding to a specific activity of >5.0×10⁶IU/mg.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4, with 0.05% Tween-20.

Endotoxin

Less than 0.1EU/μg of rMuGDNF as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

Glial cell-derived neurotrophic factor is a founding member of the GDNF family of ligands (GFL) and has been shown to interact with GFRA2 and GDNF family receptor alpha 1. It is a small protein that potently promotes the survival and morphological differentiation of various neuronal. It may also modulate local neuronal effects in distal regions of the motor neuron. GDNF Recombinant murine GDNF (monomer) contains 134 amino acids residues, which is a disulfide-linked homodimer and it shares 99% and 93%a.a. sequence identity with rat and human GDNF.

Amino Acid Sequence

SPDKQAAALP RRERNRQAAA ASPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCESAETMYD KILKNLSRSR RLTSDKVGQA CCRPVAFDDD LSFLDDNLVY HILRKHSAKR CGCI

產(chǎn)品編號

產(chǎn)品名稱

包裝

P6164-2μg

Recombinant Murine GDNF

2μg

P6164-10μg

Recombinant Murine GDNF

10μg

P6164-100μg

Recombinant Murine GDNF

100μg

P6164-1mg

Recombinant Murine GDNF

1mg

-

說明書

1份