Species

Gene ID

Accession

Source

Length

MW

Tag

Mouse

20295

F6R5P4

E. coli

70aa

7.9kDa

－

About this Antibody

Name

Recombinant Murine TARC/CCL17 (Recombinant Murine Thymus and Activation Regulated Chemokine/CCL17; rMuTARC/CCL17)；Recombinant Mouse TARC/CCL17 ; 重組小鼠胸腺活化調(diào)節(jié)趨化因子/CCL17

Synonyms

TARC; ABCD-2; CC chemokine TARC; C-C motif chemokine 17; chemokine (C-C motif) ligand 17; MGC138273; SCYA17MGC138271; small inducible cytokine subfamily A (Cys-Cys), member 17; Small-inducible cytokine A17; T cell-directed CC chemokine; TARCA-152E5.3; Thymus and activation-regulated chemokine

Purity

>97% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10ng/ml.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.

Endotoxin

Less than 1EU/μg of rMuTARC/CCL17 as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Chemokines

Background

Murine CCL17 also known as TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine and SCYA17, is encoded by the CCL17 gene located on the chromosome 8. Among CC chemokine family members, CCL17 has approximately 24–29% amino acid sequence identity with RANTES, MIP-1α, MIP-1β, MCP-1, MCP-2, MCP-3 and I-309. CCL17 is a secreted protein and expressed by thymus cells constitutively and phytohemagglutinin-stimulated peripheral blood mononuclear cells transiently. It signals through the chemokine receptors CCR4 and CCR8 and displays chemotactic activity for T lymphocytes and some other leukocytes. CCL17 play an important role in skin diseases such as atopic dermatitis, bullous pemphigoid and mycosis fungoides. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils.

Amino Acid Sequence

ARATNVGREC CLDYFKGAIP IRKLVSWYKT SVECSRDAIV FLTVQGKLIC ADPKDKHVKK AIRLVKNPRP

產(chǎn)品編號

產(chǎn)品名稱

包裝

P6812-5μg

Recombinant Murine TARC/CCL17

5μg

P6812-20μg

Recombinant Murine TARC/CCL17

20μg

P6812-100μg

Recombinant Murine TARC/CCL17

100μg

P6812-1mg

Recombinant Murine TARC/CCL17

1mg

-

說明書

1份