Products for Solid Phase Peptide Synthesis/Combinatorial Chemistry
Tulsion®CMB Polymers提供固相合成肽生物科技
特麥?zhǔn)酥圃焯厥獾燃壍亩朋?Polymers 用于生物科技固相法的肽合成步驟使用。
Thermax make  ecial Tulsion® Polymers having applications in the biotechnology area specially for solid phase peptide synthesis .
杜笙 CMB 高分子樹脂具有能應(yīng)用于肽的合成的甲基氯官能基.以此種樹脂用來合成肽的技術(shù)是由Merrified 于1963年發(fā)明。肽的化學(xué)鍵的行成是由此種樹脂的官能基與氨基酸鍵結(jié)合而來。在去除保護的官能基之后，一個個新的氨基酸分子便產(chǎn)生來增加其肽的化學(xué)鍵。 此肽的化學(xué)鍵的增長是一步一步合成而來的。在每個步驟中過濾掉多余的反應(yīng)劑。在最后的合成步驟是去除所有的保護官能基并將肽從此樹脂中分離出來。此種樹脂 的特性可以根據(jù)客戶需要制造，用來適用不同的合成步驟。它們根據(jù)嚴(yán)格的質(zhì)量標(biāo)準(zhǔn)在非常認(rèn)真的控制條件下制造。

Tulsion® CMB polymers have chloromethyl functionality and are used for peptide synthesis.Use of such polymers for peptide synthesis was initiated by Merrifield in 1963. The formation of peptide bond starts with reaction of a protected amino acid molecule with chloromethyl group on the surface of the polystyrene polymer. After removal of the protecting group, a new amino acid molecule is reacted to elongate the peptide chain. The elongation is continued with stepwise addition. Excess reagents and byproducts are removed by filtration at each step. The final step in the synthesis involves freeing up of the protecting group as well as liberating the peptidefrom the polymer. Properties of the polymers can be tailor-made to suit individual application needs.

They are made under very carefully controlled conditions using strictest quality standards.

Tulsion® CB polymers:

所有高分子合成的基礎(chǔ)是聚合物基質(zhì)。Tulsion® CB 100 / 200
是最常用的型號。固相有機合成的最重要考慮因素是樹脂的顆粒大小及膨脹因素。而膨脹因素是由樹脂本身的鍵結(jié)程度 ,水合以及物質(zhì)的特性有關(guān)。
Tulsion®CB 100 / 200 本身特質(zhì)具有很好的疏水特性并且在非極性的溶劑中膨脹。他們用于固相的有機合成與DVB 產(chǎn)生交叉鍵結(jié)而具有穩(wěn)定的機械結(jié)構(gòu).

The foundation of all polymeric synthesis is the polymeric matrix. Tulsion®CB 100 / 200 is commonly used resin. The most important characteristics considering solid phase organic synthesis are the swelling factor and the bead size of the resin. The swelling characteristics areaffected by the factors such as degree of crosslinking, hydrophobisity of substrate and nature ofthe matrix.

Tulsion® CB 100 / 200 itself is very hydrophobic in nature and swells in a non-polar solvent. It is used in solid phase organic chemistry is crosslinked with DVB to give mechanically stable matrix in presence of swelling solvents.

Tulsion®CB 100 / 200 樹脂能用于各種合成反應(yīng)，在反應(yīng)中作為甲基氯樹脂或Merrifield 樹脂(Tulsion®CMB) ,Wang Resins, 或者其他用于固相肽合成的樹脂。

Tulsion®CB 100 / 200 resins are used in variety of reactions to give Chloromethyl resins or Merrifield resins (Tulsion®CMB), Wang resins chlorotrytil resins and other resins used in solidphase peptide synthesis.

技術(shù)資料

Technical Characteristics -