ILDR2產(chǎn)品信息

英文名稱：Immunoglobulin-like domain-containing receptor 2

中文名稱：免疫球蛋白樣結(jié)構(gòu)域受體2

靶點別稱：ILDR2,C1orf32

物種：Human

標(biāo)簽：Fc Tag

屬性：Protein

標(biāo)記：Unconjugated

表達區(qū)間及表達系統(tǒng)（Source）

Human ILDR2, Fc Tag (IL2-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Glu 186 (Accession # Q71H61-1).

Predicted N-terminus: Leu 21

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 45.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

ILDR2屬于免疫球蛋白超家族?？赡軈⑴c脂質(zhì)穩(wěn)態(tài)和ER應(yīng)激途徑。ILDR2是一種新型的B7樣蛋白，具有強大的T細胞抑制活性，在免疫細胞和免疫特權(quán)和炎癥組織中表達。由ILDR2胞外結(jié)構(gòu)域和Fc片段組成的融合蛋白與活化T細胞上的推定對應(yīng)物結(jié)合，在膠原誘導(dǎo)的關(guān)節(jié)炎模型中顯示出有益作用，并消除了巨噬細胞和細胞因子刺激的T細胞自體滑膜樣共培養(yǎng)物中促炎細胞因子和趨化因子的產(chǎn)生?？傊?，這些發(fā)現(xiàn)表明ILDR2是一種新的T細胞負(fù)調(diào)控因子，在免疫相關(guān)疾病的發(fā)展中具有潛在作用，包括自身免疫和癌癥。