EREG產(chǎn)品信息

英文名稱：Epiregulin

中文名稱：表皮調(diào)節(jié)素

靶點(diǎn)別稱：EREG,EPR

物種：Human

標(biāo)簽：Fc Tag

屬性：Protein

標(biāo)記：Unconjugated

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human EREG Protein, Fc Tag (ERG-H5264) is expressed from human 293 cells (HEK293). It contains AA Val 63 - Leu 108 (Accession # O14944-1).

Predicted N-terminus: Pro

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the N-terminus.

The protein has a calculated MW of 31.7 kDa. The protein migrates as 33-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

EREG是表皮生長因子受體（EGFR）和結(jié)構(gòu)相關(guān)的erb-b2受體酪氨酸激酶4（ERBB4）的配體，其刺激EGFR和ERBB4的酪氨酸磷酸化。EREG可能參與廣泛的生物過程，包括炎癥、傷口愈合、卵母細(xì)胞成熟和細(xì)胞增殖。此外，EREG可能促進(jìn)各種人體組織癌癥的進(jìn)展。