Human ELAPOR1 Protein, His Tag

分子別名（Synonym）

ELAPOR1,Endosome-Lysosome Associated Apoptosis And Autophagy Regulator 1,EIG121,KIAA1324

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human ELAPOR1, His Tag (EL1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Thr 42 - Lys 910 (Accession # Q6UXG2-1).

Predicted N-terminus: Thr 42

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 92.3 kDa. The protein migrates as 100-120 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

內(nèi)質(zhì)體/溶酶體相關(guān)凋亡和自噬調(diào)節(jié)因子（ELAPOR1），也稱為EIG121蛋白，是一種由雌激素誘導(dǎo)的I型跨膜蛋白。它與內(nèi)體溶酶體隔室有關(guān)，可能在自噬和細(xì)胞增殖中發(fā)揮重要作用。在饑餓和暴露于細(xì)胞毒性藥物等不利條件下，ELAPOR1可能通過(guò)上調(diào)自噬途徑保護(hù)細(xì)胞免受細(xì)胞死亡。