Human CXCL16 Protein, Fc Tag

分子別名（Synonym）

CXCLG16, SR-PSOX, SRPSOX, C-X-C motif chemokine ligand 16

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human CXCL16, Fc Tag (CX6-H5254) is expressed from human 293 cells (HEK293). It contains AA Asn 30 - Thr 205 (Accession # Q9H2A7-1).

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 45.7 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

該基因編碼的蛋白質(zhì)是一種G蛋白偶聯(lián)受體，具有七個(gè)跨膜結(jié)構(gòu)域，屬于CXC趨化因子受體家族。該家族還包括CXCR1、CXCR2、CXCR3、CXCR4、CXCR5和CXCR7。該基因映射到趨化因子受體基因簇，在幾個(gè)T淋巴細(xì)胞亞群和骨髓基質(zhì)細(xì)胞中表達(dá)。編碼的蛋白質(zhì)及其唯一配體趨化因子配體16（CCL16）是調(diào)節(jié)T淋巴細(xì)胞向各種外周組織（肝、脾紅髓、腸、肺和皮膚）遷移的信號(hào)通路的一部分，并促進(jìn)細(xì)胞與樹(shù)突狀細(xì)胞和成纖維網(wǎng)狀細(xì)胞的相互作用。CXCR6/CCL16還控制駐留記憶T淋巴細(xì)胞在肺部不同部位的定位，并維持氣道駐留記憶T細(xì)胞，這是抵抗呼吸道病原體的重要第一道防線(xiàn)。編碼的蛋白質(zhì)充當(dāng)HIV-1和SIV與CD4結(jié)合進(jìn)入靶細(xì)胞的進(jìn)入輔助受體。