Human CCL27 Protein, His Tag

分子別名（Synonym）

ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human CCL27 Protein, His Tag (CC7-H5143) is expressed from E. coli cells. It contains AA Phe 25 - Gly 112 (Accession # Q9Y4X3).

Predicted N-terminus: Met

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 12.2 kDa. The protein migrates as 11 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.3 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

該基因是聚集在9號(hào)染色體p臂上的幾個(gè)CC細(xì)胞因子基因之一。細(xì)胞因子是一個(gè)參與免疫調(diào)節(jié)和炎癥過程的分泌蛋白家族。CC細(xì)胞因子是以兩個(gè)相鄰半胱氨酸為特征的蛋白質(zhì)。該基因編碼的蛋白質(zhì)對(duì)皮膚相關(guān)記憶T淋巴細(xì)胞具有趨化性。這種細(xì)胞因子也可能在介導(dǎo)淋巴細(xì)胞歸巢到皮膚部位中發(fā)揮作用。它特異性結(jié)合趨化因子受體10（CCR10）。對(duì)類似小鼠蛋白質(zhì)的研究表明，這些蛋白質(zhì)-受體相互作用在T細(xì)胞介導(dǎo)的皮膚炎癥中起著關(guān)鍵作用。