Pleiotrophin產(chǎn)品信息
英文名稱:Angiopoietin-related protein 4
中文名稱:血管生成素相關(guān)蛋白4
靶點別稱:Pleiotrophin,PTN
物種:Human
標簽:His Tag
屬性:Protein
標記:Unconjugated
表達區(qū)間及表達系統(tǒng)(Source)
Human Pleiotrophin Protein, His Tag, premium grade (PLN-H5244) is expressed from E. coli cells. It contains AA Gly 33 - Asp 168 (Accession # P21246).
Predicted N-terminus: His
該產(chǎn)品是在我們嚴格的質(zhì)量控制體系下生產(chǎn)的,該體系包含一套全面的測試,包括無菌和內(nèi)毒素測試。在早期臨床前階段,產(chǎn)品性能經(jīng)過仔細驗證和測試,以確保其與細胞培養(yǎng)用途或任何其他應(yīng)用的兼容性。當準備過渡到后期臨床階段時,我們還提供定制的GMP蛋白質(zhì)服務(wù),以滿足您的需求。我們將與您合作,根據(jù)您的要求定制和開發(fā)GMP級產(chǎn)品,該產(chǎn)品也符合細胞療法細胞制造中使用的原材料和輔助材料的要求。
蛋白結(jié)構(gòu)(Molecular Characterization)

This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 17.2 kDa. The protein migrates as 22-23 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
內(nèi)毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method.
無菌(Sterility)
Negative
支原體(Mycoplasma)
Negative.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
多效營養(yǎng)素和Midkine是結(jié)構(gòu)上相關(guān)的肝素結(jié)合神經(jīng)營養(yǎng)因子,其表達受發(fā)育調(diào)控。這些神經(jīng)營養(yǎng)因子的表達模式表明其在神經(jīng)發(fā)生、細胞遷移、次生器官發(fā)生誘導(dǎo)和中胚層上皮相互作用中起作用。PTN的表達在腦胚胎發(fā)生過程中增加,在出生時達到最大水平。PTN和Midkine的生理作用在很大程度上尚不清楚,但這些神經(jīng)營養(yǎng)因子與神經(jīng)母細胞瘤的發(fā)病機制有關(guān)。重組人多營養(yǎng)蛋白是一種15.4 kDa的蛋白質(zhì),含有136個氨基酸殘基和5個分子內(nèi)二硫鍵。
關(guān)鍵字: Pleiotrophin;PTN蛋白;多效生長因子;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。