NGFR產(chǎn)品信息

英文名稱：Low affinity neurotrophin receptor p75NTR

中文名稱：低親和力神經(jīng)營養(yǎng)因子受體p75NTR

靶點(diǎn)別稱：NGFR，TNFRSF16

物種：Human

標(biāo)簽：Fc Tag

屬性：Protein，Cell

標(biāo)記：Unconjugated

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human NGFR Protein, Fc Tag (NGR-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 29 - Asn 250 (Accession # P08138-1).

Predicted N-terminus: Lys 29

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus

The protein has a calculated MW of 50.0 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

p75神經(jīng)營養(yǎng)因子受體（p75NTR）最初被鑒定為神經(jīng)營養(yǎng)因子（NGF R）的低親和力受體。神經(jīng)營養(yǎng)因子受體結(jié)合神經(jīng)營養(yǎng)因子，包括神經(jīng)生長因子、神經(jīng)營養(yǎng)因子-3、腦源性神經(jīng)營養(yǎng)因子和神經(jīng)營養(yǎng)因子-4。所有神經(jīng)營養(yǎng)因子都與p75NTR結(jié)合。這也包括未成熟的促神經(jīng)營養(yǎng)因子形式。神經(jīng)營養(yǎng)因子受體，包括p75NTR，負(fù)責(zé)確保發(fā)育中神經(jīng)元的適當(dāng)密度與靶比，將發(fā)育中更廣泛的圖譜細(xì)化為精確的連接。p75NTR參與促進(jìn)神經(jīng)元存活和神經(jīng)元死亡的途徑。