化合物 Lexibulin dihydrochloride,Lexibulin dihydrochloride

化合物 Lexibulin dihydrochloride|T15746|TargetMol

價格	￥10600	￥17500	￥13800
包裝	25mg	100mg	50mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-12

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產(chǎn)品詳情

中文名稱:化合物 Lexibulin dihydrochloride	英文名稱:Lexibulin dihydrochloride
CAS:917111-49-0	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
產(chǎn)品類別: 抑制劑
貨號: T15746

Product Introduction

Bioactivity

名稱	Lexibulin dihydrochloride
描述	Lexibulin 2Hcl is an effective tubulin polymerization inhibitor (IC50: 10-100 nM in cancer cell lines). It also has potent cytotoxic and vascular disrupting activity in vitro and in vivo.
體外活性	CYT997 was also capable of reversibly disrupting the microtubule network in cells, visualized using fluorescence microscopy. Thus, the treatment of A549 cells with CYT997 (1 μmol/L) leads to the rapid reorganization of microtubules, including the destruction of the existing microtubule network and accumulation of tubulin in plaques within the cytoplasm of some cells. CYT997 prevented the in vitro polymerization of tubulin (IC50: ～3 μmol/L) (compared with the half-maximal inhibitory concentration of 2 μmol/L for colchicine under identical conditions) as determined using the conventional turbidimetric assay for tubulin polymerization. Only 66% of total cells were in the G1, S, and G2-M phases, at 24 hours post-CYT997 treatment, which shows that cells blocked at the G2-M boundary do not exit back to G1, as in the normal cell cycle, but most likely are driven towards apoptosis and cell death [1]. CYT997 potently inhibits proliferation, consistent with the disruption of cellular tubulin, induces cell cycle arrest, and most importantly apoptosis of both human myeloma cell lines (HMCLs) and primary MM cells [2]. Major alterations in cell morphology were evident, after 24 hours, including loss of adhesion and cell rounding. The effect of 1 hour of treatment with CYT997 was reversible and cells rapidly recovered their normal microtubule architecture. The data indicate that CYT997 belongs to the class of anticancer agents that disrupt, rather than stabilize, tubulin-containing structures. Although vehicle-treated cells show 15% and 19% in G2-M phase at 15 and 24 hours (respectively), cells treated with CYT997 (1 μmol/L) had 38% and 43% of cells in G2-M at the same time points.
體內(nèi)活性	A single dose of CYT997 (7.5 mg/kg i.p.) clearly decreased blood flow in liver metastases, and a significant reduction in blood flow was present 6 hours postdose [1]. CYT997 treatment (15 mg/kg/day) significantly prolongs the survival in a murine model of aggressive systemic myelomatosis [2]. In a xenograft model using the human prostate cancer cell line PC3, oral dosing of CYT997 was initiated 13 days after cell implantation by which time palpable tumors were evident. Dose-dependent inhibition of tumor growth was apparent with CYT997, which at the highest dose was equivalent to parenterally administered paclitaxel.
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
關(guān)鍵字	CYT997 Dihydrochloride \| Lexibulin Dihydrochloride \| CYT997 \| Lexibulin \| CYT-997 \| CYT 997 \| CYT-997 Dihydrochloride \| Lexibulin dihydrochloride \| CYT 997 Dihydrochloride

關(guān)鍵字： CYT-997 dihydrochloride|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學家的研究提供專業(yè)的產(chǎn)品和服務。TargetMol?品牌的客戶群分布于40多個國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學試劑盒等，此外，我們還建設(shè)有CADD（計算機輔助藥物設(shè)計）研究中心、藥理實驗室、藥化合成平臺三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務、快速高效的全球供應鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （12年）	注冊資本	566.265100萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生化試劑,分子生物學,分子砌塊,生物技術(shù)服務	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務

TargetMol中國（陶術(shù)生物）

VIP 3年

公司成立：12年
注冊資本：566.265100萬人民幣
企業(yè)類型：有限責任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑、藥物篩選化合物庫、藥物篩選等
公司地址：靜安區(qū)江場三路238號8樓

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化合物 Lexibulin dihydrochloride|T15746|TargetMol相關(guān)廠家報價

產(chǎn)品名稱	價格		公司名稱	報價日期
917111-44-5CYT997 (Lexibulin)	詢價	VIP3年	上海嘉定區(qū)澄瀏公路52號	2024-12-25
CYT997 (Lexibulin) (Microtubules抑制劑)	詢價		碧云天生物技術(shù)有限公司	2024-12-25
RAVIDASVIR DIHYDROCHLORIDE	詢價	VIP5年	陜西締都醫(yī)藥化工有限公司	2024-12-18

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