化合物 Apogossypolone (ApoG2),Apogossypolone (ApoG2)

化合物 Apogossypolone (ApoG2)|T21786|TargetMol

價格	￥10600	￥17500	￥13800
包裝	25mg	100mg	50mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-02-28

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產(chǎn)品詳情

中文名稱:化合物 Apogossypolone (ApoG2)	英文名稱:Apogossypolone (ApoG2)
CAS:886578-07-0	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
產(chǎn)品類別: 抑制劑
貨號: T21786

Product Introduction

Bioactivity

Name	Apogossypolone (ApoG2)
Description	Apogossypolone (ApoG2) is a semi-synthesized derivative of gossypol which is a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins with K i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis [1] and autophagy [2]. Apogossypolone also has antifungal activity [3].
In vitro	Apogossypolone (ApoG2) shows better stability under stressed conditions [1]. Apogossypolone (0-1 μM, 72 or 96 h) inhibits WSU-DLCL 2 cells growth in a dose-dependent manner [1]. Apogossypolone (0-5 μM, 24 or 48 h) interferes with the formation of heterodimers between anti-apoptotic and pro-apoptotic Bcl-2 family members, and leads to cleavage of caspase-3, caspase-9 and PARP [1]. Apogossypolone (0-8 μM, 0-72 h) induces apoptotic WSU-DLCL 2 cell death in a time- and dose-dependent manner [1]. Apogossypolone (0-10 μM, 0-24 h) induces autophagy and promotes ROS generation in HCC cells [2]. Cell Proliferation Assay [1] Cell Line: WSU-DLCL 2 Concentration: 250, 350, 500 and 1000 nM Incubation Time: 96 h for cell counting, 72 h for MTT Result: Inhibited growth in a dose-dependent manner. The 50% growth inhibition concentration (IC 50 ) was approximately 350 nM. Western Blot Analysis [1] Cell Line: WSU-DLCL 2 Concentration: 0.35, 0.5, 1 and 5 μM Incubation Time: 24 or 48 h Result: Blocked the formation of heterodimers between Bcl-X L and Bim in a concentration-dependent manner. Resulted in the activation of cleavages of caspase-3, caspase-9 and PARP. Apoptosis Analysis [1] Cell Line: WSU-DLCL 2 Concentration: 0, 1, 2, 4 and 8 μM Incubation Time: 24, 48 and 72 h Result: Induced cell apoptosis in a time- and dose-dependent manner. Cell Autophagy Assay [2] Cell Line: HepG2 and Hep3B Concentration: 1.25, 2.5, 5 and 10 μM Incubation Time: 6, 12, 18 and 24 h Result: Induced LC3 (Light chain 3)-II conversion in a dose- and time-dependent manner.
In vivo	Apogossypolone (ApoG2) (120 mg/kg; i.v. or p.o.; once a day for 5 days) can effectively inhibit growth of diffuse large cell lymphoma cells without toxicity [1]. Animal Model: Four-week-old female ICR-SCID mice, each mouse received 10 7 WSU-DLCL 2 cells (in serum-free RPMI 1640) subcutaneously (sc) in each flank area [1] Dosage: 120 mg/kg Administration: Intravenous or administration per day for five days Result: Inhibited the growth of WSU-DLCL 2 and significantly decreased the tumor weight. Animal Model: Non-tumor-bearing SCID mice [1] Dosage: 160 mg/kg Administration: Intravenous or administration per day for five days Result: Was well tolerated in mice up to 800 mg/kg. Displayed no gross signs of toxicity.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Keywords	Apogossypolone (ApoG2) \| Apogossypolone \| ApoG2

關(guān)鍵字： Apogossypolone (ApoG2)|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計算機輔助藥物設(shè)計）研究中心、藥理實驗室、藥化合成平臺三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （12年）	注冊資本	566.265100萬人民幣
員工人數(shù)	100-500人	年營業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

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公司成立：12年
注冊資本：566.265100萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑、藥物篩選化合物庫、藥物篩選等
公司地址：靜安區(qū)江場三路238號8樓

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